ConsumerLab.com uses JavaScript to provide the best possible experience for our content, but your browser has it disabled. Learn how to enable it here.

About ConsumerLab.com

Saffron Supplements

Supplements made with saffron extracts have been the focus of many small clinical studies for depression and anxiety, sleep, and cognition. But are they effective, and which saffron supplements deliver the right dose and best quality? See what ConsumerLab's independent testing and review revealed.

Saffron Supplements Review

Search term may appear only in full report available to members. Join now for full access.

News Release

February 13, 2023

Saffron Supplements Vary Widely in Key Compounds, According to ConsumerLab Tests

White Plains, New York, February 13, 2023 — Saffron extracts are promoted to treat mood, improve cognition and vision, and even reduce appetite.

Product Review

Vision Supplements Review (with Lutein, Zeaxanthin & AREDS2 Formulas)

Find the Best Vision Supplement Based Our Tests

CL Answer

What are the best supplements for depression and anxiety?

Best natural supplements for depression and anxiety, including the evidence for fish oil, vitamin D, probiotics, and herbal supplements for depression such as curcumin (from turmeric) and saffron.

Best Supplements for Depression and Anxiety -- sad young woman sitting on couch, looking toward the window

CL Answer

AGZ for Sleep – Is It Worth It?

AGZ claims to "support restful, restorative sleep" without melatonin, but is there evidence to support this use and is it worth its price? Find out.

AGZ packets

Recalls & Warnings

December 12, 2022

FDA Warns Saffron USA for Promoting Teas to Treat Insomnia, Osteoporosis & Cancer

On September 23, 2022, the FDA issued a warning letter to Saffron USA LLC following inspection of the company’s website which found statements about its Allergy Blend, Chamomile Tea Petals, Diabetic Support Blend, Orange Blast Tea, and Saffron Loose Tea products to be drug ...

Recalls & Warnings

December 01, 2021

FDA Warns Seller of Saffron Supplements

On November 18th, 2021, the FDA issued a warning letter to Saffron Health Sciences following a review of the company's website, social media, and Amazon product listings, which found statements made about the company's products Crocin Rich, Crocin Rich II, and Crocin Rich ...

CL Answer

I take warfarin (Coumadin), an anticoagulant drug. Are there supplements I should avoid, or be taking, due to this drug?

Find out which supplements should be avoided when taking blood thinners (anticoagulants) like warfarin (Coumadin), including vitamin K, St. John's wort, and curcumin.

Warfarin Supplement Interactions -- bottle of pink warfarin tablets

CL Answer

Which supplements and lifestyle changes improve sleep, and which cause insomnia?

Find out which vitamins may help you sleep and learn if any vitamins or supplements can cause insomnia.

CL Answer

What supplements should I stop taking before surgery?

Info on which supplements to avoid before surgery due to increased risk of bleeding or interference with anesthesia.

Supplements to stop before surgery - operating room

CL Answer

Do any supplements help relieve stress?

Are there actually supplements for stress relief and panic attacks? Learn more about holy basil, fish oil, L-theanine, and ginseng.

CL Answer

Can supplements, natural eye drops, or lifestyle modifications improve symptoms of dry eye?

Can supplements such as fish oil, flaxseed oil or curcumin (from turmeric) help treat dry eyes? Find out, including formulas and doses that have shown benefit. Also, learn if drinking more water or using eye drops containing castor oil, N-acetylcarnosine or aloe can help with dry eye.

Older man with dry eye rubbing his eyes while holding his glasses

CL Answer

Are there supplements I should avoid when taking apixaban (Eliquis) or similar blood thinner drugs like Xarelto?

Learn about supplement interactions with apixaban (Eliquis), rivaroxaban (Xarelto) and other blood thinner drugs in the direct factor Xa inhibitors class.

Eliquis Supplement Interactions -- box of Eliquis

CL Answer

Do any supplements help with COVID-19? Do supplements like vitamin D, zinc, vitamin C, or herbals work?

Find out if natural remedies & supplements for coronavirus such as zinc, vitamin C, garlic, or elderberry help to prevent or treat COVID-19.

Supplements for Coronavirus (COVID-19)? -- mask and pills

CL Answer

Which supplements help reduce the risk of colorectal cancer?

Find out which supplements may reduce the risk of colorectal cancer, including folate, fiber, selenium, and vitamin D.

Supplements and Colorectal Cancer Risk -- colon cancer diagnosis form and supplements

Recalls & Warnings

August 07, 2025

Herbalife “Relaxation Tea” Recalled

On July 21, 2025, Herbalife International of America recalled 5,888 units of its Relaxation Tea because an incorrect ingredient was received from the supplier and used in the manufacturing ...

Recalls & Warnings

November 09, 2023

FDA Warns Biorica International for Cholesterol, Kidney & Cancer Claims

On August 4, 2023, the FDA issued a Warning Letter to Biorica International Corp. following review of the company’s websites and social media, which found statements about the company’s Plaquex Oral Supplements to be drug claims, which are not permitted for dietary supplements.

Recalls & Warnings

December 29, 2022

EarthLab, Inc. Warned for Promoting Curcumin, Elderberry to Treat Pain & Flu

On November 10, 2022, the FDA issued a warning letter to EarthLab, Inc., dba Wise Woman Herbals following inspection of the company’s website which found statements about the company’s products to be drug claims because they suggest the products can prevent or treat disease.

Recalls & Warnings

March 01, 2023

Seller of Dr. Miller’s Herbal “Detox” Teas Warned by FDA for Drug Claims

On February 3, 2023, the FDA issued a warning letter to Jackson Health & Wellness Clinic after inspection of the company’s website found statements about the company’s Dr. Miller’s Holy Tea, Dr. Miller’s Super Holy Tea, Dr. Miller’s Ultimate Tea, Dr.

Recalls & Warnings

May 04, 2023

FDA Warns MedoLife for Promoting Homeopathic Products to Treat COVID-19, Cancer

On April 19, 2023, the FDA issued a warning letter to Medolife Rx D/B/A MedoLife Corp., AELIA Inc. and Queanta Inc.

Recalls & Warnings

May 24, 2023

Seller of Echinacea, High Blood Pressure Products & More Warned for Drug Claims

On May 12, 2023, the FDA issued a warning letter to H.E.A.L.

Recalls & Warnings

December 22, 2021

FDA Warns Seller of Liquid Magnesium, B-12, Berberine & More

On December 9, 2021, the FDA issued a warning letter to Wholly Liquid Nutritional Supplements LLC because it found statements on the company's website and social media about its products, including SpiroLaze, BioLaze, LiquiLaurin, VIT-B12, DeStress, and Omega Plus, to be ...

Recalls & Warnings

March 09, 2022

FDA Warns Seller of Magnesium, CBD, Herbal Extracts & More

On February 9, 2022, the FDA issued a warning letter to Bea Lydecker’s Naturals, Inc.

Recalls & Warnings

August 16, 2023

FDA Warns Hekma Center, LLC for Promoting Products to Treat Anemia, Diabetes, Depression, & More

On June 2, 2023, the FDA issued a warning letter to Hekma Center, LLC following review of the company’s website and social media, which found statements about the company’s Natural Supplements for Anemia, Lymf (Galium aparine), Natural Supplements for Cardiomyopathy, Magic1 (Moringa ...