Summary
Does L-citrulline work?
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What is L-citrulline?
L-citrulline (or citrulline) is a non-essential amino acid that the body can convert to L-arginine, which is necessary for the body's production of nitric oxide, a compound that relaxes blood vessels and allows more blood to flow through arteries. (See What It Is) - Despite much hype, clinical studies of L-citrulline for exercise performance and cardiovascular uses have shown only modest to no benefit. Only one small study suggests that L-citrulline benefits men with mild erectile dysfunction. Studies on benefits for brain function, such as after stroke, have been limited to those in mice. (See What It Does)
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Which is the best L-citrulline supplement?
Among products shown to be accurately labeled in our tests (one product was not) and that passed our tests for heavy metals such as lead (see What CL Found), we selected Top Picks for L-citrulline as a powder and as a pill, both of which provide L-citrulline at relatively low cost. -
Is L-citrulline malate a better form?
Both L-citrulline and L-citrulline malate can raise levels of L-citrulline in the body, but there are several reasons why we prefer the L-citrulline form. (See What to Consider When Buying) -
L-citrulline safety and side effects:
L-citrulline supplementation appears to be generally safe and well tolerated in healthy individuals, although occasionally, gastrointestinal upset and heartburn have been reported, and it should be used with caution by people on medication that lowers blood pressure. (See Concerns and Cautions)
