6/27/2015

How Vitamin B-12 Causes Acne

Vitamin B-12 is a critical nutrient and many people, particularly those over 50, should supplement with B-12 to avoid deficiency. However, at doses higher than those used to prevent deficiency, B-12 may occasionally trigger acne. A new study appears to explain the B-12/acne connection. For details, see the "Cobalamin (B-12)" section of the B Vitamin Supplements Review >>

8/10/2021

Best Form of B-12 for Vegans?

What form of vitamin B-12 appeared best at raising B-12 levels among people on plant-based diets in a new study, and how did this compare to getting B-12 from plant-based foods? Find out in the B-12 section of our B Vitamin Supplements Review. Also see our Top Picks for vitamin B-12.

12/09/2024

B-12 Plus Intrinsic Factor?

Do vitamin B-12 supplements with “intrinsic factor” boost blood levels of B-12 better than B-12 alone? Find out what research suggests in the B-12 section of our B Vitamin Supplements Review, which includes our Top Picks for B-12.

3/19/2025

Bad B-12 Supplements Sold on Amazon

Eleven out of 23 vitamin B-12 supplements sold on Amazon and tested by a competing brand contained less B-12 than listed on labels, including two with no detectable B-12. Get the details in our B Vitamin Supplements Review, which includes our Top Picks for B-12, B-complexes, and other B vitamin supplements.

11/21/2024

Laughing Gas & B-12

Although rare, be aware that use of nitrous oxide (i.e. laughing gas), such as during a medical procedure, can inactivate vitamin B-12 in the body. Let medical professionals know if you are B-12 deficient. Get the details in the B-12 section of our B Vitamin Supplements Review. Also see our Top Picks for vitamin B-12 and other B vitamin supplements.

2/15/2022

B-12 Deficiency and GI Symptoms

Severe vitamin B-12 deficiency can cause a range of gastrointestinal symptoms, as highlighted in a recent case. Learn about these and other symptoms of B-12 deficiency in the B-12 section of our B Vitamin Supplements Review. Also see our Top Picks for vitamin B-12 and other B vitamin supplements.

7/13/2021

Hidden Forms of B-12 Deficiency

Vitamin B-12 deficiency can occur even in people with "normal" blood levels of B-12, as was most recently reported in a 30-year-old man. Learn more, including the wide range of symptoms of B-12 deficiency and information about testing for B-12 deficiency in our B Vitamin Supplements Review. Also see our Top Picks for B-12.

8/25/2020

B-12 Supplements vs. Injections

Can taking a B-12 supplement work as well as an injection to correct vitamin B-12 deficiency? See what a new study found in the B-12 section of the B Vitamin Supplements Review. Also see our Top Picks for vitamin B-12 and other B vitamin supplements.

10/31/2023

Can B-12 cause allergic reactions?

Although rare, vitamin B-12 can cause allergic reactions, but so can “inactive” ingredients in B-12 and other supplements. For details see the Risks of B-12 section of our Vitamin B-12 Review, which includes our Top Picks for B-12.

12/24/2021

Oral Symptoms of B-12 Deficiency

Vitamin B-12 deficiency can cause a range of symptoms in the mouth, as described in a recent report. Learn about oral and other symptoms of B-12 deficiency in the B-12 section of our B Vitamin Supplements Review. Also, see our Top Picks for B-12 and other B vitamins.

6/13/2023

Vitamin B-12 Allergy

Rarely, vitamin B-12 supplementation can cause an allergic reaction, as highlighted by a recent case. Be aware of the risks of B-12 as explained in our B Vitamin Supplements Review, which includes our Top Picks for vitamin B-12 and other B vitamins.

8/25/2023

B-12 for Ringing Ears?

Low levels of B-12 have been linked with tinnitus (ringing in the ears) and other issues, but does taking B-12 reduce tinnitus? Find out in the B-12 section of our B Vitamin Supplements Review, which includes our Top Picks for B-12 and other B vitamins.

Also see our article about supplements that may improve or worsen tinnitus.

2/04/2022

Risk of Too Much B-12

It’s easy to get way more vitamin B-12 than one needs from supplements. Unfortunately, high blood levels of B-12 are being linked to higher risks of death and disease, as shown in a recent U.S. study. Get the details in the Upper Limit for B-12 section of our B Vitamin Supplements Review. Also, see our Top Pick among B-12 supplements.

8/15/2024

Best Way to Take B-12?

What’s the best way to take vitamin B-12? Find out more in our article about vitamin B-12. Also see our Top Picks for vitamin B-12 in our B Vitamin Supplements Review.

6/07/2024

Oral B-12 for Deficiency?

Can taking vitamin B-12 by mouth treat B-12 deficiency, or are injections necessary? Find out what a recent study showed in the Oral B-12 vs Injection section of our B Vitamin Supplements Review, which includes our Top Pick for high-dose B-12.

2/06/2025

Why High-Dose B-12?

A CL member asked why so many B-12 supplements contain very high doses of B-12, such as 1,000 mcg or more. Find out when this is, and isn't, appropriate in our article about B-12. Also see our B Vitamin Supplements Review for our Top Picks for vitamin B-12.

12/23/2020

B-12 for Eczema?

Can vitamin B-12 deficiency worsen eczema and can supplementing with B12 help? Find out what happened in a recent case in the vitamin B-12 section of section of our B Vitamin Supplements Review. Also, see our Top Picks for vitamin B-12.

1/10/2017

Potential Risk with High B-12

Among people who are malnourished, those with elevated vitamin B-12 levels in their blood were twice as likely to die when hospitalized as those with lower B-12 levels, according to a new study. The study authors suggest caution with inappropriate supplementation. For more details about the study, and vitamin B-12, see the B Vitamin Supplements Review >>

11/18/2020

B-12 for Singers

It is commonly believed that a shot of vitamin B-12 improves the performance of professional singers. A placebo-controlled study put this belief to the test. Get the results in the B-12 (cobalamin) section of our B Vitamin Supplements Review. Also see our Top Picks for B-12 and other B vitamins & complexes.

1/18/2022

B-12 Vitamin Deficiency and Darkening of the Skin

Low levels of vitamin B-12 can cause darkening of the skin, as evidenced in a recent case. Get the details and learn about other symptoms of B-12 deficiency in our B Vitamin Supplements Review. Also, see our Top Picks among B-12 supplements.

12/05/2024

Difficulty Walking and B-12 Deficiency

Be aware that vitamin B-12 deficiency may present with a variety of neurologic symptoms, including difficulty walking due to spinal cord degeneration, as described in a recent report. Get the details in the B-12 section of our B Vitamin Supplements Review, which includes our Top Picks for vitamin B-12.

8/29/2023

Symptoms of B-12 Deficiency

Be aware that vitamin B-12 deficiency can cause a range of side effects. Among these are low blood cell counts, as described in a recent case report. Get the details in the Symptoms of B-12 deficiency section of our B Vitamin Supplements Review.

Also see our Top Picks for B-12 and other B vitamins.

11/29/2019

B Vitamins for Cognition

Increasing vitamin B-12 intake by those deficient in B-12 can help slow age-related declines in memory and cognition, but the dose needs to be sufficient, as suggested by a recent study. For details see the Memory, Cognition, and Alzheimer's Disease section of the B Vitamin Supplements Review. Also see our Top Picks for B-12 and other B Vitamins.

4/05/2022

B-12 Deficiency Can Cause Reversible Cognitive Decline

Treating B-12 deficiency improved rapid cognitive decline and stopped hallucinations in an older man, according to a recent report. Get the details in the B-12 section of our B Vitamin Supplements Review. Also see our Top Picks for B-12 and other B vitamins.

11/27/2024

B-12 Deficiency & GI Symptoms

Vitamin B-12 deficiency can cause many symptoms, including chronic diarrhea, as described in a recent report. Learn about symptoms of B-12 deficiency in our B Vitamin Supplements Review, which includes our Top Picks for B-12.

12/14/2013

B-12 Deficiency and Acid Inhibitors

A large, new study found the risk of vitamin B-12 deficiency to be significantly higher among people taking proton pump inhibitors (e.g., Prevacid, Prilosec) or H2-blockers (e.g., Pepcid, Zantac) than among those not taking these medications. The drugs reduce acid production in the stomach, but acid is needed to release B-12 from foods, so deficiency can occur. B-12 supplements can help because acid is not needed for their absorption. For details -- and our reviews of supplements with vitamin B-12 -- see the updated B Vitamin Supplements Review,   

For more information, see ConsumerLab's answer to the question, I take omeprazole (Prilosec), a proton pump inhibitor, to reduce stomach acid. Are there supplements I should avoid, or be taking, due to this drug?.

9/06/2024

Side Effect of High-Dose B-12

Although there is no established upper limit on intake of vitamin B-12, too much can cause a side effect noted in several case reports. Get the details in the Vitamin B-12 section of our B Vitamin Supplements Review, which includes our Top Picks among B vitamins.

12/16/2012

Higher Vitamin Level May Slow Cognitive Decline

An 8-year study of people in their 70's found that cognitive functioning (memory and other mental skills) declined faster among those with lower blood levels of vitamin B-12 compared to those with higher levels. Particularly surprising was that 40% of the people in the study fell into the lower B-12 group, many of whom had levels which would not normally define them as deficient in B-12. This and other recent studies suggest a role for vitamin B-12 in minimizing cognitive decline in older people. For details, see the updated B Vitamin Supplements Review. More >>

6/28/2022

B-12 Deficiency & Stomach Surgery

Many people who have had bariatric (stomach-reducing) surgery need to supplement with B-12 and other B vitamins. Find out what happened to such a person who discontinued supplementation in the Vitamin B-12 section of our B Vitamin Supplements Review.

5/03/2022

Severe B-12 Deficiency Can Be Missed

B-12 deficiency can cause severe symptoms, even when B-12 levels in the blood are not low, as shown in a recent case. Find out why, and which tests can help, in the B-12 section of our B Vitamin Supplements Review.

3/25/2022

B-12 Deficiency in Infants

Although not common, B-12 deficiency can occur in infants. A recent study showed common symptoms and risk factors. Learn about B-12 deficiency in infants as well as in men and women in the B-12 section of our B Vitamin Supplements Review.

6/14/2024

B-12 for Vegans

What happens when a vegan stops supplementing with B-12? Find out in the Vegan section of our B Vitamin Supplements Review. Also see our Top Picks for B-12 and other B vitamin supplements.

1/08/2012

B-12 and Folic Acid for Memory

Small but significant improvements in short and long-term memory were found to occur in older people (aged 60 to 74) given modest daily amounts of vitamin B-12 and folic acid. But don't expect immediate results. Improvements were seen only after 2 years of supplementation. See the update in the B Vitamins Review for the dosage used, as well as our ratings of supplements with vitamin B-12 and folic acid.

4/26/2022

B-12 for Nighttime Leg Cramps

Raising lower blood levels of vitamin B-12 may help with nighttime leg cramps according to some reports. Get the details in the B-12 section of our B Vitamin Supplements Review.

For information about other supplements that may help, see our answer to the question: Do any supplements, foods, or oils help reduce muscle pain, muscle cramps, or nighttime leg cramps?

8/02/2022

Metformin and B-12 Deficiency

If you take metformin for diabetes, be aware that you are at risk for vitamin B-12 deficiency. See the latest guidelines to monitor for this in the B-12 section of our B Vitamin Supplements Review.

11/11/2022

Nutritional Yeast for B Vitamins?

Is nutritional yeast a good source of B-12 and other B vitamins? That depends on whether or not it is fortified. Get the details in the Getting B-12 from food section of our B Vitamin Supplements Review, which includes a list of foods containing B vitamins.

7/15/2022

B Vitamins for Parkinson's?

People with Parkinson's disease tend to have lower levels of vitamin B-6 and B-12. Find out if supplementing with B-6 or B-12 is beneficial and whether B-6 can interfere with drugs for Parkinson's.

7/26/2022

B-6 or B-12 for Anxiety?

Can taking high-dose vitamin B-6 or B-12 improve self-reported anxiety? Find out what a recent study showed in the Anxiety section of our B Vitamin Supplements Review.

Also see our answer to the question: What are the best supplements for depression and anxiety?

8/09/2022

B-12 and Insomnia?

A CL Member had trouble sleeping when taking high dose B-12 to correct a deficiency and asked us if this is common. Find out in the B-12 section of our B Vitamin Supplements Review.

Also see: Supplements That May Help or Worsen Insomnia.

6/12/2016

B Vitamins & Autism Risk

Excessive blood levels of B-12 and/or folate in pregnant women were found to be associated with an increased risk of autism in their children, according to a new study. While these vitamins are critical, too much may be problematic. Get the details in the B-12 and Folate sections of the B Vitamin Supplements Review >>

1/20/2017

Side-Effect With B-12

Certain formulations of vitamin B-12 contain additional ingredients that can cause diarrhea and bloating in some people — particularly if taking more than one pill. An apparent case of this was reported to us this week. To help you avoid this, read the details in the "What CL Found" section of the B Vitamin Supplements Review (which includes our tests of products) >>

10/25/2022

Symptoms of B-12 Deficiency

Vitamin B-12 deficiency can cause a wide range of adverse effects affecting the nervous system, cognition, blood and blood pressure, and more. Learn about the symptoms and recent cases, and find out who is most likely to be deficient in our B Vitamin Supplements Review.

Also see our article: Top 8 Supplements for Vegetarians and Vegans.

4/08/2022

Vitamin B-12 Deficiency and Dementia

Correcting B-12 deficiency may improve cognition in people with dementia, according to a recent study and case reports. Get the details in the Memory, Cognition, and Alzheimer’s Disease section of our B Vitamin Supplements Review.

10/30/2011

B Vitamins May Help Memory

A recently published study of individuals aged 70 years or more with mild cognitive impairment found that a daily dose of three B vitamins (folic acid, vitamin B-12, and vitamin B-6) over 2 years appeared to slow cognitive and clinical decline, particularly in those who started with elevated levels of plasma homocysteine. See the B Vitamin Product Review for details including the dosage used.  More >>

9/21/2013

B Vitamin Supplements for Stroke?

A review of 14 clinical studies suggests that B vitamins may help prevent stroke. However, a deep reading of the report shows the benefit to be slight, at best.  For details about the study, other uses of B vitamins (including B6, B-12, folic acid, niacin and complexes), and tests of these supplements, see the B Vitamin Supplements Review>>  

11/16/2014

Do B Vitamins Boost Memory?

This week, a study was reported in the media suggesting that taking vitamin B-12 and folic acid does not help with memory. But a closer look at this and related studies shows a benefit for some people. Get the details, plus our tests and comparisons of B-vitamin supplements, in the B Vitamin Supplements Review >> 

7/25/2023

Best Way to Take B Vitamins?

We’ve added information about the best way to take vitamins B-6, B-12, and folate to our article about the best way to take vitamins and minerals.

2/11/2020

Vitamin B12 and Risk of Death

A study found higher blood levels of vitamin B12 to be associated with an increased risk of death -- suggesting caution when supplementing. For details, see the B-12 section of the B Vitamin Supplements Review. If you do need to supplement with B12, see our Top Pick among products.

3/07/2018

B12 Dosage

A study compared the effects of a high weekly dose of vitamin B12 versus a much lower dose given daily. Both worked equally well. Find out why and get more details about B12 dosing in the B-12 section of B Vitamin Supplements Review.

12/08/2023

Dementia & Folic Acid

Taking folic acid without getting enough B-12 has been linked to increased risk of Alzheimer’s disease and dementia. Learn more in the Folate section of our B-Vitamin Supplements Review, which includes our Top Picks among B-Complexes.

Also see: Do any supplements, foods or lifestyle modifications help with brain function, like memory and cognition?

7/05/2016

Folic Acid Supplementation Mitigates Alzheimer's

A recent study in people with Alzheimer's disease found that folic acid supplementation decreased inflammation and slightly improved mental functioning. However, participants began the study unusually low in folic acid relative to normal U.S. levels. For more details see the B Vitamin Supplements Review >> Also see results of a folate/B-12 study which showed reduced brain shrinkage in Alzheimer's patients.

3/24/2023

Plant-based Sources of B-12?

Find out if there are good plant sources of B-12, if certain foods can increase the availability of zinc, and if vegetarians or vegans should supplement with taurine.

1/28/2022

B-12 From Chlorella and Spirulina?

A reader asked if chlorella and spirulina are good sources of B-12. The answer is both "yes" and "no," as explained in our Greens and Whole Foods Powders and Pills Review, which includes our recent tests result and Top Picks for chlorella and spirulina supplements.

9/28/2021

Supplements During Chemotherapy?

If you are getting chemotherapy, experts now recommend avoiding acetyl-L-carnitine. Also, see what they have to say about using alpha-lipoic acid, vitamin B-12 and vitamin E.

7/20/2019

Zinc for Canker Sores?

We've added information about zinc to our answer to the question: Can lysine, vitamin B-12, or other vitamins or minerals help prevent or reduce canker sores?

10/07/2024

Seaweed for Vegetarians

Eating a serving of nori, a type of seaweed, can improve vitamin B-12 status among vegetarians. Seaweed can also provide iodine. But there are caveats. Get the details in our Seaweed Snacks and Foods Review, which includes our Top Pick among seaweed snacks.

Also see: Top 8 vitamins and nutrients for vegetarians and vegans

6/10/2017

Hip Fracture Risk With Too Much B-6

A new study found that older men and women who took a high daily dose of vitamin B-6 had a 42% increased risk of hip fracture. Get the details in the "Vitamin B-6" section of the B Vitamin Supplements Review. Also, be aware that many supplements on the market contain the amount of B-6 used in this study, or more, in a daily serving! For help choosing a B-Complex or B-6 supplement that suits your needs without providing too much B-6, see our Top Picks among B vitamin supplements.

2/22/2023

Symptoms of Too Much B-6

High doses of vitamin B-6 from supplements may cause adverse effects, even when doses do not exceed the established tolerable limit for B-6, as highlighted by a recently reported case. Learn about getting too much or too little vitamin B-6 in our B Vitamins Supplements Review, which includes our Top Picks among B-6 and other B vitamin supplements.

12/19/2023

Caution With High-Dose B Vitamins

Vitamin B-6: Regularly taking a higher than required dose of vitamin B-6 may cause nerve damage, as was recently reported. Get the details in the B-6 section of our B Vitamin Supplements Review.

Niacin: A large increase in niacin dosage may cause fainting, as was recently reported. Get the details in the Niacin section of our B-Vitamin Supplements Review.

11/04/2017

B Vitamins for Memory

Many studies suggest that adequate intake of B vitamins slows age-related declines in memory and cognition. This was recently shown again in a study in England. Find out which B vitamins help, and how much you need, in the "What It Does" section of the B Vitamin Supplements Review >> [Also see our Top Picks for B vitamin supplements in the Review.]

10/04/2022

Nerve Pain & Vitamin B-6

Vitamin B-6 deficiency can cause nerve pain and weakness, even resulting in inability to walk, as shown in a recent case. However, getting too much B-6 from supplements can also cause these symptoms. Find out how much B6 you should be getting in the Vitamin B-6 section of our B Vitamins Supplements Review.

For information about supplements that may help with other forms of nerve pain, see our answer to the question: Do any supplements, like Nervive, help with nerve pain, like sciatica or diabetic neuropathy?

9/19/2023

Does B-6 Reduce Antibiotic Side Effects?

Did supplementation with vitamin B-6 reduce antibiotic-related side effects in people treated for H. pylori infection (a common cause of peptic ulcers)? Find out in our B Vitamin Supplements Review, which includes our Top Picks for vitamin B-6 and other B vitamins.

Also see: 8 Supplements That May Help Treat Peptic Ulcers – And Some to Avoid

10/24/2024

B Vitamin Confusion

Be aware that a B complex supplement Approved by us in 2022 has a similar name to a product NOT Approved in our most recent tests. The two products are different, as explained in the What CL Found section of our B Vitamin Supplements Review, which includes our current Top Picks for B vitamin complexes and single B vitamins.

4/07/2025

Caution With Vitamin B-6

Taking more than the recommended daily allowance of vitamin B-6 may cause nerve damage, according to recent case reports. Get the Details in the B-6 section of our B Vitamin Supplements Review, which includes our Top Pick for B-6 (that should only be used if you’re deficient).

5/27/2013

Alzheimer's Changes Slowed with B Vitamins

A combination of B vitamins was found to slow brain loss in areas of the brain associated with Alzheimer's disease. This same combination of vitamins has also been shown to slow cognitive decline. Get the details on who may (or may not) benefit, dosage, plus test results for over 35 B vitamin supplements in the updated B Vitamin Supplements Product Review >>

8/02/2022

Increasing Folate from Beans & Peas

Beans and peas are great dietary sources of folate (vitamin B-9), but the right preparation can more than double their folate levels, according to a recent study. Find out how in the Folate section of our B Vitamin Supplements Review.

Also see our table of Foods Containing B Vitamins to find out other foods that are good sources of folate and other B vitamins.

4/29/2022

MTHFR Mutations and B Vitamin Deficiencies

People with a certain MTHFR gene mutation (C677T) may be more likely to develop B vitamin deficiencies. But what about those with a less common MTHFR mutation – A1298C? Find out what research suggests in the MTHFR gene mutation and B vitamin metabolism section of our B Vitamin Supplements Review.

8/26/2017

High-Dose B Vitamins & Cataract Risk

Taking high doses of B vitamins, including B vitamin complexes, folic acid and B6, was associated with a higher risk of age-related cataracts among middle-aged men and women, according to a new study. For details, see the "ConsumerTips" section of the B Vitamin Supplements Review >>

10/09/2018

Can a B Vitamin Lower High Blood Pressure?

A common mutation of the MTHFR gene is associated with an increased risk of hypertension. A recent study tested whether supplementing with a specific B vitamin could reduce blood pressure in affected individuals. Get the results in the MTHFR section of the B Vitamin Supplements Review. (Also see our Top Picks among B vitamins.)

8/06/2020

B Vitamins and Fracture Risk

High homocysteine levels have been linked with increased fracture risk in older people. Taking B vitamins can lower homocysteine levels, but does it lower fracture risk? Find out what a recent study using folic acid and B12 showed in the What It Does section of the B Vitamin Supplements Review. Also see our Top Picks for B vitamins.

8/14/2021

Danger With Too Much B-6

A CL member recently told us about a friend who developed progressively worsening neuropathy (nerve damage) after taking very high dose vitamin B-6. It's important to be aware of the upper daily limit for vitamin B-6 and that taking too much can cause nerve damage, as well as skin lesions and other adverse effects, as discussed in detail in our B Vitamin Supplements Review.

7/08/2022

B-5 for Arthritis?

Can vitamin B-5 supplementation improve symptoms of rheumatoid arthritis or osteoarthritis? Find out what research suggests in the B-5 (Pantothenic Acid) section of our B Vitamins Supplements Review.

12/14/2017

Danger from Too Much Vitamin B6

A women who was consuming large amounts of an energy drink as well as a B-vitamin complex developed symptoms of vitamin B6 (pyridoxine) toxicity (which may not be reversible), according to a recent report. Get the details in the "B6" section of B Vitamin Supplements Review >>

CL has long warned that energy drinks and shots often contain large amounts of B6 and other B vitamins.

5/28/2019

Vitamin B12 & Depression

Deficiencies in B vitamins, such as B12, can cause depression. A recent study suggests that, in pregnant women, even low-normal B12 levels are associated with a much higher risk of depression. For details, see the Depression section of the B Vitamin Supplements Review. Also see our Top Picks for B vitamins.

10/24/2018

B Vitamin Cancer Risk?

Giving high-dose vitamin B12 along with a modest amount of folic acid to older people was found to significantly increase the risk of colorectal cancer. See the B12 section of the B Vitamins Review for details. (Also see our Top Picks for B12 and other B vitamins.)

11/04/2020

Muscle Cramps from Lack of Vitamin

Painful muscle cramps in an older person resolved after correcting a deficiency in one of the B vitamins, according to a new report. Get the details, and learn which conditions and medications increase the risk of this deficiency, in the B Vitamin Supplements Review. Also see our Top Picks for B vitamin supplements.

5/20/2012

B Vitamin May Lower Blood Pressure

According to a new study, approximately 10% of the population is genetically prone to high blood pressure which may respond dramatically to a low dose of riboflavin (vitamin B-2). Read the update to the B Vitamin Supplements Review for details, including the dose used and amount of blood pressure reduction achieved. More >>

9/01/2020

Folate & Memory

Older people with high blood levels of folate are more likely to perform worse on tests of memory and cognition unless they have sufficient levels of another B vitamin, according to a recent study. Get the details in the What It Does section of our B Vitamin Supplements Review. Also see our Top Picks among B vitamin supplements.

5/18/2019

Hip Fracture Risk with B6

Another study has shown a significantly increased risk of hip fracture with high intakes of vitamin B6 from supplements. For details, see the B-6 section of the B Vitamins Review. Also see how much B6 is in popular B vitamin supplements and our Top Picks.

10/02/2024

Benfotiamine & Alzheimer’s

Can taking benfotiamine (a derivative of vitamin B-1) slow cognitive decline in people with mild cognitive impairment or Alzheimer’s disease? See what research suggests in our B Vitamins Supplements Review, which includes our Top Picks among B vitamins.

Also see: Do any supplements, foods or lifestyle modifications help with brain function, like memory and cognition?

9/19/2024

Niacin-Induced Liver Failure

Be aware of the risk of liver injury from use of very high dose niacin, as recently reported in an otherwise healthy, young woman who was taking niacin to manage anxiety and depression. Get the details in the Niacin (Nicotinic Acid) (B-3) section of our B Vitamin Supplements Review, which includes our Top Picks for B vitamins.

Also see: Is there a risk of liver toxicity with certain supplements?

3/15/2024

Carcinogen in Folic Acid

Several folic acid supplements were recently recalled in Canada due to a carcinogenic impurity that can occur with folic acid (vitamin B-9). For details, see the Quality Concerns section of our B Vitamins Review, which includes our Top Picks for folic acid and B complexes.

11/28/2017

Growing Concern with Biotin Causing False Lab Results

Biotin (a B vitamin found in B-complex and hair and nail supplements) can interfere with laboratory results resulting in the missed diagnosis or misdiagnosis of cardiovascular and hormonal conditions, such as Graves' disease (a form of hyperthyroidism). Physicians and lab personnel may be unaware of this interference. For details, see the "Biotin" section of the B Vitamins Review >>

5/24/2017

POTS and Thiamin

A small study among people who suffer from POTS (postural tachycardia syndrome) suggested that supplementing with thiamin (vitamin B-1) may help some. For details, see the Thiamin (B-1) section of the B Vitamin Supplements Review >>

12/05/2017

Biotin Interference With Vitamin D Test

Last week we reported that high doses of biotin (found in B complexes and hair and nail supplements) can interfere with certain blood tests. A study recently showed that biotin can also artificially inflate a test for vitamin D. Get the details in the "Biotin" section of the B Vitamin Supplements Review >>

1/08/2019

B Vitamins & Breast Cancer

A reduced risk of breast cancer was associated with supplementing with certain amounts of folic acid and vitamin B12 for women predisposed to breast cancer in a new study. See the details in the "Breast cancer" section of the B Vitamin Supplements Review.

2/25/2020

Cognitive Impairment From B12 Deficiency

Vitamin B12 deficiency can cause a wide range of symptoms. This includes cognitive impairment, as shown in a recent case. For details about the symptoms of B12 deficiency see the B12 section of the B Vitamin Supplements Review. Also see our Top Picks for B12 and other B vitamin supplements.

8/29/2017

High-Dose B Vitamins & Lung Cancer Risk

A recent study found that taking high doses of vitamins B6 and B12 was associated with an increased risk of lung cancer among men, particulary among those who smoke. For details, see the "ConsumerTips" section of the B Vitamin Supplements Review >>

11/26/2017

Signs of B12 Deficiency

B12 deficiency is not uncommon, most often affecting older people. Symptoms include anemia, fatigue, tingling in the arms and legs and loss of balance -- but a recent case report highlights a lesser-known sign of B12 deficiency. Find out more, plus how much B12 you should get in the "B12" section of the B Vitamins Review >> (Also see our Top Picks for vitamin B12 and other B vitamins.)

7/16/2019

Is Methylfolate the Best Form of Folate?

Methylfolate has been promoted as a better form of folate (vitamin B9), particularly for people with certain common genetic variations. A clinical study recently put methylfolate to the test against folic acid and folinic acid. The results were surprising. Get the details in the Folate section of the B Vitamin Supplements Review. Also see our Top Picks among folate and other B vitamin supplements.

8/13/2019

Folic Acid and Colon Cancer

Several studies have evaluated whether folate from food and/or folic acid from supplements affect cancer risk. Find out what a recent report suggests about long-term, high-dose folic acid supplementation in the Folate section of the B Vitamin Supplements Review. Also see our Top Picks for folic acid and other B vitamin supplements.

4/28/2020

Early Sign of Thiamin Deficiency

Thiamin (vitamin B1) deficiency can cause lasting neurologic damage and affect heart function. It can occur with poor nutrition and as a result of taking certain diuretics. A recent case highlighted an early sign of thiamin deficiency that involves the eyes. We've added this information to the Thiamin section of the B Vitamin Supplements Review. Also see our Top Pick for thiamin and B complexes that contain thiamin. You can also get thiamin from a good multivitamin.

7/20/2019

Is Niagen Safe?

Niagen (nicotinamide riboside) was recently studied for its safety and ability to raise NAD+ in the body. See the results and learn more about this form of niacin (which is also in the product Basis) in the Niacin section of the B Vitamin Supplements Review. Also see our Top Picks for niacin and other B vitamin supplements.

12/23/2017

Folic Acid for Cognition

Giving folic acid to older people with relatively low levels of blood folate resulted in improved cognitive performance, according to a recent study. For details, see the "Memory, Cognition, and Alzheimer's Disease" section in the B Vitamin Supplements Review >> (Also see our Top Picks for folate and other B vitamin supplements.)

11/20/2018

Liver Toxicity With Niacin

The death of a woman from acute liver failure highlights the risk of a particular formulation of high-dose niacin. For details, see the Niacin section of the B Vitamin Supplements Review. (Also see our Top Picks for niacin and other B vitamins.)

11/11/2020

Biotin for MS?

High-dose biotin was tried in people with multiple sclerosis (MS) to see if would reverse MS-related disability. Find out if it helped the Biotin section of the B Vitamin Supplements Review. Also, learn about concerns with high-dose biotin and see our Top Picks for biotin and other B vitamin supplements.

2/03/2021

Thiamin Deficiency from Bowel Disease

People with inflammatory bowel disease (such as Crohn’s or colitis) can develop thiamin (vitamin B-1) deficiency, which can lead to life-threatening brain injury, as noted in a recent review of 31 cases. Learn more about this and other causes of thiamin deficiency in the Thiamin section of our B Vitamin Supplements Review.

1/20/2016

Omega-3's May Be Important in Preventing Cognitive Decline

We have reported in the past that a certain combination of B vitamins slowed cognitive decline as well as brain shrinkage in older people. Now, further analyses finds that these benefits only occurred in people having certain blood levels of omega-3 fatty acids (as found in fish oil). Get the details in the B Vitamins Supplements Review >>

7/19/2014

High-Dose Niacin with Statins Not Worth It

Further evidence was published this week showing that the addition of high-dose niacin (vitamin B-3) to cholesterol-lowering treatment with statin drugs provides no worthwhile benefit and appears to increase the risk of adverse side events. For details, see the Review of B Vitamin Supplements and Energy Drinks >> 

8/20/2016

Biotin Caution

Very high-doses of biotin (vitamin B-7) can cause misleading laboratory results and lead to unnecessary antithyroid treatment, according to a new report. For details, see the Biotin section of the B Vitamins Supplements Review >>

1/13/2018

B12 for Cognition

Numerous studies show that getting adequate intake of B vitamins, such as B12, and, perhaps, omega-3 fatty acids from fish, may slow age-related declines in memory and cognition. But not everyone should expect a benefit, as shown in a recent study. For details, see the Memory, Cognition, and Alzheimer's Disease section of the B Vitamin Supplements Review. (Also see our Top Picks among products.)

10/22/2016

Too Much Folate & Nerve Damage

One quarter of American men and women have a gene variation which puts them at higher risk of nerve damage if consuming too much of folate (vitamin B-9) daily, according to a new study. Considering that most older Americans consume more than this amount (largely due to excessive supplement use) this should be a warning to many. For more details, see the "Folate" section of the B Vitamins Review >>

5/16/2015

Niacin Reduces Skin Cancer

A recent study suggests that high-dose niacin (vitamin B-3) may reduce the risk of developing certain types of skin cancer. A closer look at the study, however, raises questions about its relevance to people in North America. Get the details, as well as more information about niacin and our product test results & comparisons, in the B Vitamin Supplements Review >> 

3/15/2015

Folic Acid Reduces Risk of Stroke

A large study in people taking blood pressure-lowering medication found that the addition of a daily folic acid (vitamin B-9 or folate) supplement significantly reduced the chance of having a stroke. This benefit is most likely to occur among people whose blood levels of folate are low. More details, including dosage and ConsumerLab.com's test-based quality ratings of folic acid supplements, are found in the B Vitamin Supplements Review >>

5/09/2011

Does folic acid affect the risk of colon cancer?

Supplementation with higher amounts of folic acid (vitamin B-9) has been shown to increase the risk of prostate cancer, but its effect on the risk of colon cancer has been unclear. A new study found no increase in colon cancer due to folic acid supplementation. But if you supplement with folic acid, be careful. See the B Vitamin Supplements Review for more >>

3/23/2021

Folic Acid and Colorectal Cancer

Do higher intakes of folic acid and other sources of folate increase or decrease the risk of colorectal cancer? It may depend on time, according to a new study discussed in the Folate section of our B Vitamin Supplements Review. Also see our Top Picks among B vitamin supplements.

9/26/2023

Allergic Reaction to Folic Acid

Although rare, severe and life-threatening allergic reactions to folic acid from supplements have been reported. Get the details about this, as well as risks from too much folic acid, in the Folic Acid section of our B Vitamin Supplements Review, which includes our Top Picks for folic acid and folate, and other B vitamins.

9/29/2023

Nail Growth

Does biotin help nails to grow faster? Find out what research suggests, and also learn which topical treatment for hair growth may help nails to grow, in the Biotin section of our B Vitamin Supplements Review, which includes our Top Picks for biotin and other B vitamins.

1/06/2023

Best Way to Get B Vitamins?

Is it better to get B vitamins through supplements, foods, or a combination of the two? See our answer.

9/30/2022

Folic Acid & Risk of Self-Harm

Can taking folic acid (vitamin B-9) reduce the risk of self-harm and suicide? Find out what a recent study found in the Depression section of our B Vitamin Supplements Review.

2/02/2024

Thiamin for Fibromyalgia?

Can taking thiamin reduce symptoms of fibromyalgia? Find out in the Thiamin section of our B Vitamin Supplements Review. Also see our Top Picks among B vitamins.

Also see: Can any supplements improve or worsen symptoms of fibromyalgia?

1/20/2025

Nicotinamide for Glaucoma?

Some preliminary research suggests nicotinamide (a form of niacin) may help with glaucoma, but is this recommended? Find out in our B Vitamins Supplements Review, which includes our Top Picks among B vitamin supplements.

8/19/2022

B-6 Depleted by Parkinson’s Drug?

Can vitamin B-6 levels in the body be depleted by carbidopa, a drug taken in combination with levodopa for Parkinson's disease? Find out what evidence suggests in our updated CL Answer about supplements for Parkinson's disease.

10/07/2022

Biotin for Skin Health?

Biotin has been promoted for reducing wrinkles, but does clinical research support this? Find out in the Biotin (B-7) section of our B Vitamin Supplements Review, which also discusses the evidence for biotin for treating brittle nails and hair loss.

Also, see our CL Answer about supplements for reducing wrinkles and tightening the skin.

7/22/2022

B-6 or Zinc for Pyrrole Disorder?

Can supplementing with vitamin B-6 or zinc improve psychiatric conditions associated with pyrrole disorder? Find out by using the links.

6/01/2022

Too Much B-6 After Stomach Surgery?

People who have had gastric bypass, gastric sleeve, or gastric band surgery may be supplementing with too much B-6 after surgery, according to a recent study. Get the details in our updated article about the Best Vitamins to Take After Bariatric Surgery.

12/09/2022

Thiamin Alternative?

Is thiamin tetrahydrofurfuryl disulfide (TTFD), a derivative of thiamin, absorbed and used by the body better than thiamin itself? Find out, and learn about possible health effects, in the Thiamin (B-1) section of our B Vitamin Supplements Review.

8/18/2023

Brand Change at Walgreens

Walgreens has rebranded its "Finest Nutrition" supplements. Get the details in our B Vitamins Review.

9/21/2019

Vitamin B12 & Sleepiness

Vitamin B12 deficiency can cause a range of symptoms and, although rare, excessive daytime sleepiness is among them. Get the details about this, as well as information about other symptoms of B12 deficiency, in the B12 section of the B Vitamins Supplements Review. Also see our Top Pick for vitamin B12.

7/26/2017

How Vitamin B6 May Backfire

Supplementing with high-dose vitamin B6 can sometimes cause the same nerve toxicity associated with deficiency of B6. New research explains why this may happen and suggests how to avoid it. For details, see the "Vitamin B6" section of the B Vitamin Supplements Review >>

6/20/2017

Warning: Biotin Can Affect Thyroid Tests

Vitamins that contain megadoses of biotin (vitamin B7) can affect thyroid tests, according to recent studies. This can lead to an incorrect diagnosis of hyperthyroidism and improper treatment. See the "Biotin" section of the B Vitamin Supplements Review >>

5/15/2018

Too Much Vitamin B6

Be aware that you can get too much vitamin B6 from supplements and energy drinks. This can result in nerve damage and other adverse effects, as has been recently reported. For details, see the B6 section of the B Vitamin Supplements Review.

1/15/2019

B12 Tablet vs. Injection

Is a vitamin B12 tablet just as good as an injection for raising blood levels of B12? Find out in the Cobalamin (B12) section of the B Vitamin Supplements Review. Also see our Top Pick for vitamin B12.

12/14/2019

B12 & the Vegetarian

Vegetarians and vegans are susceptible to vitamin B12 deficiency, which can be manifest by a range of health issues, including low blood pressure, as recently reported in an otherwise healthy young man. Learn more in the B12 section of the B Vitamin Supplements Review. Also see our Top Pick for vitamin B12.

1/31/2021

B12 for Diabetic Neuropathy?

Can high-dose vitamin B12 improve nerve function and reduce pain in people with neuropathy due to type 2 diabetes? See what a new study found in the B12 section of the B Vitamin Supplements Review. Also see our Top Picks for vitamin B12.

2/03/2017

Cognitive Decline With Too Little B6

A recent study among men and women in their 60's found that those getting inadequate amounts of vitamin B6 in their diets had much higher rates of cognitive decline. Get the details in the "What It Does" section of the B Vitamin Supplements Review (which includes our tests of products) >>

10/29/2017

Best form of B12?

It's important for many older adults and people using medications that reduce stomach acid to take a vitamin B12 supplement. Three different forms of B12 are sold. A recent study suggests that one may be better than another. Get the details in the B12 (cobalamin) section of the B Vitamin Supplements Review >> [Also see our Top Pick for B12 supplements in the Review.]

5/15/2020

High Blood Pressure Risk With Too Much Folic Acid During Pregnancy

While it is important to take folate during pregnancy, a new study suggests that too much folic acid from supplements increases the risk of high blood pressure in mothers. See the details in the Folic Acid section of the B Vitamin Supplements Review.

Also see our Top Pick among prenatal vitamins, which provides adequate (but not too much) folic acid, in our Multivitamin and Multiminerals Supplements Review.

5/18/2019

Misdiagnosed B12 Deficiency

Vitamin B12 is needed to make the genetic material in all cells. Consequently, B12 deficiency can cause a wide range of symptoms and may be misdiagnosed as other diseases. Read about two recent cases of misdiagnosed B12 deficiency in the Cobalamin (B12) section of the B Vitamin Supplements Review. Also see our Top Picks for B12.

6/20/2017

B12 Can Cause Acne

Taking very large doses of vitamin B12 can cause outbreaks of acne -- even in older people, according to a recent report. Learn more in the "B12" section of the B Vitamin Supplements Review >>

12/26/2017

Folic Acid & Risk of Autism

Supplementing with adequate (and not excessive) folic acid around the time of conception is associated with a lower risk of autism in offspring, and a recent study suggests this may be particularly important for women who take antiepileptic medication. For details, see the "Folate" section of the B Vitamin Supplements Review >> (Also see information about getting folic acid from prenatal vitamins in the "Prenatal" section of the Multivitamin Review.)

1/08/2012

Additional Nutrients For the Brain

An new study found that various nutrients and fats in the blood correlate with better brain functioning and brain volume in the elderly (mean age of 87). Higher levels of B vitamins and vitamins C, D, and E, as well as marine omega-3 fatty acids (EPA and DHA) appeared helpful. On the other hand, higher levels of trans-fats (from hydrogenated oils) had a negative impact. You can learn more about each of these nutrients in our various reports. An abstract of the study is online.

6/02/2023

Biotin Caution With Lab & At-Home Tests

High doses of biotin from supplements can interfere with a wide range of laboratory and at-home tests, including those for pregnancy, doping, COVID, and heart attacks. Get the details in the Biotin section of our B Vitamin Supplements Review.

Also see: Which vitamins and supplements should be stopped before getting blood work and laboratory tests?

1/31/2023

B12 Deficiency & Metformin

If you take metformin to treat diabetes, be aware that you are at higher risk of vitamin B12 deficiency. Recent laboratory research suggests a possible reason for this, as discussed in the ConsumerTips section of our B Vitamins Review. Also see our Top Picks among B12 supplements.

5/04/2024

Thiamin Deficiency After Bariatric Surgery

Having bariatric surgery can lead to vitamin deficiencies in people who do not follow recommended supplementation. This was recently reported in three individuals who developed thiamin deficiency after gastric bypass surgery. Get the details in the Thiamin section of our B Vitamin Supplements Review.

Also see our Top Pick among multivitamins for people who have undergone bariatric surgery and our article about supplements to take or avoid after bariatric surgery.

3/03/2025

Biotin Caution With Lab Tests

Taking high-dose biotin can cause blood tests to show falsely high levels of testosterone and/or cortisol, as shown in recent cases. It can interfere with many other tests, as well. Get the details, in the Biotin section of our B Vitamin Supplements Review. Also see our Top Picks for biotin.

Also see: Which vitamins and supplements should be stopped before getting blood work and laboratory tests?

2/18/2025

PFAS in Oral-B?

Does Oral-B Glide Advanced Bacteria Defense Floss contain PFAS (“forever chemicals”)? Find out in our article about PFAS, which includes our Top Picks among flosses, dental picks, and dental tapes, and information for more than 85 different products.

11/20/2011

No Benefit of Niacin with Statins

According to a recently published study, high dose niacin added to statin drug treatment does not further reduce the risk of heart attacks and stroke despite improvements in levels of HDL cholesterol and triglycerides. In fact, there was a small increase in strokes among those taking niacin. However, a role remains for high dose niacin in lipid treatment. For details, see the update to the B Vitamin Supplements Review.

2/17/2013

Autism and Folic Acid Supplements

A new study found that women who took folic acid supplements around the time of conception had a significantly reduced risk of bearing a child with autistic disorder. Get more details in the recent update to the folic acid section of the B Vitamins Review >>

4/14/2013

Concern Over Carnitine Causing Cardiovascular Disease

Intake of L-carnitine from supplements (and from red meat) may foster atherosclerosis (hardening of the arteries), according to new research. Once ingested, L-carnitine is converted in some people to a compound which reduces the normal clearing of cholesterol from arteries.

For more details, see the updated reviews of B Vitamin Supplements & Energy Drinks and Protein Powders, as some of these products contain L-carnitine. The Acetyl-L-Carnitine Supplements review has also been updated because acetyl-L-carnitine is chemically similar to L-carnitine, suggesting a potential concern.

3/17/2013

Concern Over Niacin

You may have heard that a recent study suggests that supplementing with niacin at high doses does more harm than good. This appears to be true in only certain situations. Get the facts in the update to the B Vitamin Supplements Review >>

11/18/2012

Caution with Energy Drinks

The FDA has released reports showing deaths and other serious adverse events associated with the use of energy drinks like 5-hour Energy. As ConsumerLab.com reported in September, these small "shot" drinks can pack more caffeine than 2 cups of regular coffee. While the caffeine can keep you alert, there are a number of concerns to bear in mind and suggestions on how to more safely use these drinks. Learn more in the update to our B Vitamins and Energy Drinks Review. More >>

4/03/2018

What Niagen Does

Niagen (nicotinamide riboside) has been promoted as an anti-aging supplement. Find out what's been shown in clinical studies, including one published recently, in the Niacin section of the B Vitamin Supplements Review.

5/22/2018

Hair & Nail Supplements Can Skew Lab Tests

There are reports of high-dose biotin (common in "hair and nail" supplements) causing false readings on blood tests. Be sure to tell your doctor if you're taking high-dose biotin. Get the details in the Biotin section of the B Vitamin Supplements Review.

6/12/2018

Methylfolate vs. Folic Acid

Methylfolate (L-5-methylfolate, sold as Metafolin and Quatrefolic) is a form of folate promoted for use by people with common genetic mutations that affect the MTHFR enzyme. But is it really better than folic acid? A study recently tested them head-to-head. Get the results in the Folate section of the B Vitamins Review. Also see our Top Picks among methylfolate and folic acid products.

7/10/2018

Niagen for Blood Sugar Control?

Niagen, a brand of nicotinamide riboside (a form of niacin), was recently tested in a clinical trial to control blood sugar levels. Get the results in the Niacin section of the B Vitamins Review. (Also see our Top Picks among niacin supplements.)

9/19/2017

Niacinamide for Alzheimer's Disease?

Niacinamide (a form of niacin) has been promoted as a way to protect against memory loss associated with Alzheimer's disease – a claim based on studies in mice. A recent study put this to the test in people. See the results in the "Niacin" section of the B Vitamin Supplements Review >>

4/19/2017

Niacin & Skin Cancer

People who don't get enough niacin each day may be able to lower their risk of developing squamous cell skin cancer by getting a bit more niacin from their food or supplements suggests a recent analysis. However, this doesn't mean you should overdo it. For details, see the "Niacin" section of the B Vitamin Supplements Review. You can also find foods high in niacin using the food table in the report.

10/08/2014

Energy Drinks: Athletic Performance & Side Effects

A recent study found that a caffeinated energy drink improved athletes' self-perceived muscle power, but also increased insomnia and nervousness. Get the details in the update to the B Vitamin Supplements and Energy Drinks Review >> 

11/17/2014

Keep Energy Drinks Away from Kids

It was reported this week that 40% of calls to poison centers for "energy drink exposure" involved children under age 6, many of whom experienced serious side effects. For more about this and other concerns with energy drinks, as well as our test results for popular products, see the B Vitamins & Energy Drinks Review >> 

10/24/2015

Niacin Helps Prevent Skin Cancers

A study published this week showed that taking a form of niacin daily significantly lowered the rate of new basal-cell and squamous-cell skin cancers in patients with a history of such cancers. For details about the supplement and dose, see the B Vitamins Review >>

9/16/2016

Getting Too Much Folic Acid

Researchers recently warned that many people who use supplements may be over-consuming synthetic forms of folate, which carries risks. Current labels are misleading. Get the details in the Folate section of the B Vitamins Review >>

10/11/2016

Niagen Form of Niacin May Cause Flushing

Niacin is known to cause flushing (redness) and skin tingling at moderate doses. Other forms of niacin are said cause less flushing. One of these is Niagen. However, results of a recently published study suggest that it can cause flushing and "hotness" after just a single dose. More details are in the "Niacin" section of the B Vitamin Supplements Review >>

2/10/2021

Energy Drinks and Blood Pressure

Which people are more likely to have cardiovascular side effects from energy drinks? Find out what a new study showed in the Energy Drinks & Shots section of our B Vitamins Supplements Review.

2/28/2021

Folic Acid for Cognitive Function?

Does folic acid supplementation help with cognitive function in older people? Find out what a new study showed in the Memory and Cognition section of our B Vitamin Supplements Review. Also, see our Top Picks for folic acid.

1/13/2021

Nicotinamide Riboside to Slow Aging and Reverse NAD+ Decline?

Nicotinamide riboside, a form of niacin, has been promoted to slow aging, partially based on the belief that it raises NAD+ levels that fall with age. A new study raises doubts about this. Get the details in the Niacin section of our B Vitamin Supplement Review. Also, learn about a concern with taking too much nicotinamide riboside.

11/01/2019

Eye Risk With High-Dose Niacin

Very high doses of niacin are sometimes used to lower high cholesterol, but there are risks -- including damage to the eye, as shown in a recent case. Get the details in the Niacin section of the B Vitamin Supplements Review.

2/16/2019

Energy Drinks & Aggression

Are people who frequently consume energy drinks (like 5-hour Energy) more likely to be aggressive or have mental health problems? Learn what a new study found, and learn more about the pros and cons of energy drinks in the Energy Drinks section of the B Vitamin Supplements Review.

2/29/2020

Biotin May Skew Many Blood Tests

If you take a high-dose biotin supplement, be aware of the growing list of blood tests with which it may interfere. See the latest information in the Biotin section of the B Vitamin Supplements Review.

6/19/2019

NAD+ and Cancer?

Supplements that raise NAD+ levels in the body have been promoted for anti-aging effects. But there is a theoretical risk that they could stimulate cancerous cells, and a CL member reported this week that a supplement containing such an ingredient, nicotinamide riboside, appeared to increase his PSA level. Learn more in the Niacin section of the B Vitamin Supplements Review.

2/25/2018

Folic Acid, Multis & Autism Risk

The use of a folic acid or multivitamin supplement during pregnancy was associated a reduced risk of autism spectrum disorder in children according to a recently published study. Be aware, however, that high-dose folic acid during pregnancy may have negative effects. For details, see the Folic Acid section of the B Vitamins Review.

11/11/2019

Platelet Concern With High-dose Niacin

Long-term use of high-dose niacin may lower platelet counts. Learn more in the Niacin section of the B Vitamin Supplements Review.

10/09/2021

Niagen for Energy?

The maker of Niagen (a supplement containing nicotinamide riboside) was challenged regarding its claim that Niagen boosts energy and performance. See how the company responded in the Nicotinamide Riboside section of our B Vitamins Supplements Review.

11/15/2021

High-dose Folate for Depression

My psychiatrist told me to take high-dose of methylfolate to improve the effectiveness of my antidepressant. Is there evidence for this and is it safe? Find out in the Folate section of our B Vitamins Review.

8/28/2021

Biotin Interference With COVID Tests

Be aware that taking biotin (vitamin B-7) may interfere with COVID-19 antibody tests. Learn which tests are affected. Also find out about other laboratory tests (including thyroid and cardiovascular tests) that can be affected by biotin.

5/18/2021

Folic Acid for Hot Flashes?

Can folic acid supplementation reduce hot flashes or improve mood in postmenopausal women? See what a new study found in the B Vitamin Supplements Review.

7/10/2021

Niacin for Parkinson's?

Can niacin supplementation improve symptoms or slow decline in people with Parkinson's disease? See what a new study found in the Niacin section of our B Vitamin Supplements Review.

Also see our answer to the question: Do supplements help with Parkinson's disease treatment or prevention?

12/19/2024

When Taking Niacin Is Crucial

Although not common, be aware that niacin deficiency can cause pellagra – a condition characterized by delusions, diarrhea, and scaly skin sores. Taking niacin can rapidly reverse these symptoms. Learn more, including conditions that can cause niacin deficiency, in the Niacin section of our B Vitamins Review, which includes our Top Pick for niacin.

2/23/2024

Heart Concern with High-Dose Niacin

New research suggests a negative effect of high-dose niacin, possibly explaining why it doesn’t reduce cardiovascular disease despite improving cholesterol levels. For details, see the Niacin section of our B Vitamins & Complexes Review, which includes our Top Picks among products.

5/03/2022

Niacin & Shock-like Symptoms

Taking very high doses of niacin can cause symptoms resembling anaphylactic shock, as was recently reported. Get the details in the Niacin section of our B Vitamin Supplements Review.

9/28/2022

Don't Forget About Riboflavin

A baby was recently born with severe riboflavin deficiency due to a lack of riboflavin in the mother's vegan diet and supplements. Learn more about riboflavin requirements in our B Vitamin Supplements Review.

2/03/2023

Niacin & Cancer?

The NAD booster, nicotinamide riboside, might promote growth of existing cancers. Is there similar risk with niacin and niacinamide (nicotinamide)? Find out what evidence suggests in the Concerns and Cautions section of our NAD Booster Supplements Review.

Also, see our Top Pick among niacin supplements in our B Vitamin Supplements Review.

5/31/2011

Niacin Concern Stops Cardiovascular Study

A clinical trial using high dose niacin (vitamin B₃) was recently stopped by the National Institutes of Health due to lack of benefit and a small increase in strokes. Patients in the study had cardiovascular disease and were already taking a statin drug to keep LDL ("bad") cholesterol levels low. The addition of high dose niacin was intended to increase HDL ("good") cholesterol, reduce elevated triglycerides, and, most importantly, reduce the risk of heart attacks and stoke. For more information, including the amount and type of niacin used in the study and additional information about niacin and niacin supplements, see the B Vitamin Supplements Review. More >>

4/08/2017

Exercise Benefit Lost With High-Dose Vitamins

Older men asked to perform resistance (strength) training for 12 weeks showed less gain in bone density if they were given high daily doses of vitamins C & E than if they were given a placebo. This is not the first time that  high-dose antioxidant supplements have been shown to reduce benefits from exercise. For details, see the "Concerns and Cautions" section of the Vitamin C Supplements Review >>

2/22/2017

Does Your Multivitamin Have Too Much Folic Acid?

Folic acid is in multivitamins because it is provides the essential B vitamin, folate. Getting too much folate, however, carries risks. What most people don't know is that you actually get 70% more folate from folic acid than labels currently reveal and many supplements expose you to amounts of folate which are not only way above what you need but over the daily limit for tolerable intake. Companies now have until mid-2018 or later correct their labels, but until then you may be in the dark.

To find out which multivitamins exceed the tolerable limit for folate, see the update in the Multivitamins Review. You'll also learn how the daily requirements for many other nutrients have changed and differ from what labels currently tell you.

9/06/2017

Lower Cognitive Function in Kids Linked to High Prenatal Folic Acid

Children of mothers who took high amounts of folic acid around the time of pregnancy had lower cognitive and verbal scores when tested at 4 to 5 years of age, according to a new study. Similarly, as we reported last year, pregnant women with higher levels of folate (from folic acid) had offspring with higher rates of autism. While it is important that pregnant women get a moderate amount of folic acid to prevent spinal cord defects, higher amounts should be avoided. See the Folate section of the B Vitamin Supplements Review for details.

3/11/2012

Vitamin D Effect on Body Fat and Cholesterol

As we have reported earlier, adequate intake of vitamin D may decrease the risk of cardiovascular disease. A new study may help explain why. A 12-week course of vitamin D given to overweight women lead to a boost in HDL ("good" cholesterol) as well as a decrease in body fat. However, total body weight did not change and there was an increase in LDL ("bad") cholesterol, although it appeared to be less plaque-forming in nature. For details, including the dose given, see the updated information in the Vitamin D Supplement Review. More >>

8/23/2022

How to Get UV-A Protection from Sunscreen

UV-A radiation from the sun causes wrinkles and age-spots. Many people don't realize that SPF values on sunscreens refer only to UV-B protection. Find out what to look for on labels to determine UV-A protection.

We've also updated our list of sunscreens made with safer ingredients.

3/15/2022

Probiotics to Lower Marker of Heart Attack Risk?

Some probiotics have been shown to modestly lower high cholesterol levels. Can they also lower levels of apolipoprotein B (apoB), a strong predictor of heart attack risk? See what recent research shows in the What It Does section of our Probiotics Supplements Review.

10/04/2022

Two More Home COVID Tests Compared

We've added information about tests from Celltrion and Indicaid to our comparisons of 12 home antigen tests for COVID.

2/02/2024

Dirtiest Fruits

Find out which 12 fruits and vegetables have the most pesticides even after washing, and what to do about it, in our article about cleaning produce.

11/15/2021

Protection from Past COVID Infection?

Find out if past COVID-19 infection protects against re-infection 12 months later based on two recent studies.

5/27/2013

Probiotic Reduces Abdominal Fat

A study found that giving overweight people a strain of probiotic as part of a milk drink led to reductions in abdominal fat over 12 weeks. Those receiving the drink without the probiotic had no improvement. Get details in the updated Probiotic Supplements Review >>

2/17/2013

Risk from Too Much Calcium from Supplements

A major study found that adequate intake of calcium from the diet and other sources was associated with a lower risk of men and women dying from cardiovascular disease over the 12-year period of the study. HOWEVER getting over a certain amount of calcium from supplements was associated with 20% higher risk of men dying from cardiovascular disease. For more information, see the recent update to the Calcium Supplements Review >>

5/31/2015

Probiotic May Aid Fat Loss

A recent study in overweight men and women showed a small decrease in fat among those taking a probiotic for 12 weeks. Other small studies have shown similar benefits using different probiotics. More details, along with our reviews of probiotics containing organisms similar to those in these studies, are found in the Probiotic Supplements Review >>

10/05/2021

Pfizer Efficacy Among Adolescents

How effective is the Pfizer vaccine against Delta variant infections among adolescents 12 to 15? See what a recent study found.

4/30/2024

Probiotic for Boosting Testosterone?

Did taking a probiotic boost testosterone levels in men? Find out what a recent study showed in the Other conditions section of our Probiotics Supplements Review, which includes our Top Picks.

Also see: 10 Supplements That May Boost Testosterone (And 12 That May Not)

3/22/2024

New Top Pick Prenatal Multivitamin

Concerned by problems recently identified with 11 of 12 prenatal multivitamins in recent tests, we purchased and tested additional prenatal supplements, leading us to change our Top Pick. Learn why in the Top Picks section of our Multivitamin Supplements Review, which includes multis for men, women, children, and pets.

2/04/2022

Shelf-Lives of Home COVID-19 Antigen Tests

If you’re storing a test for future use, be aware that shelf-lives range from just 5 ½ months to 12 months from time of manufacture. See how shelf-lives of popular brands compare.

Also see our Top Picks among antigen tests based on their accuracy and other features.

5/24/2022

2nd Booster Recommendations

The CDC has strengthened its recommendation for the 2nd booster for people 50 and older and those 12 and older who are immunocompromised. Find out what prompted this change in our updated CL Answer about COVID-19 vaccines.