What is hesperidin, what is it used for and is it safe?

Written by Meredith Worthington, Ph.D. — Medically reviewed and edited by Tod Cooperman, M.D.

Updated August 10, 2021 ⓘ

A glass of orange juice sitting on a table and surrounded by sliced and whole oranges

Answer:

Hesperidin is a bioflavonoid found in oranges, lemons and other citrus fruits. It has shown anti-inflammatory, analgesic, antioxidant, anticancer, antiviral, and blood pressure lowering effects in laboratory studies (Garg, Phytother Res 2001). Based on these and other biological effects, hesperidin has been evaluated for numerous conditions, including heart health, problems with circulation, stroke, cognitive function, depression, cancer and other conditions, but evidence of benefit is limited and often mixed.

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