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Our Members Asked:
Do supplements help with Parkinson’s disease treatment or prevention?
Answer:
There is no convincing evidence that dietary supplements help delay progression or improve motor impairment in people with Parkinson's disease unless they are deficient in nutrients, although some may help with non-motor symptoms, such as sleep disturbance, depression, and psychoses.
Sign in to learn what has been shown with vitamins D and E, niacin, vitamins B-6 and B-12, coenzyme Q10 (CoQ10), melatonin, creatine, S-adenosyl-L-methionine (SAMe), N-acetyl-cysteine (NAC), valerian, magnesium, curcumin, cannabidiol (CBD), mannitol, PEA (palmitoylethanolamide), and CDP-choline (citicoline), as well as with coffee and the Mediterranean and MIND diets. Also, learn about Mucuna pruriens as a natural source of levodopa (L-dopa) and if labels on supplements are accurate.
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Helen21009
November 01, 2024There are studies favoring the use of citicoline and palmitoylethanolamide for symptom improvement and reduced use of Parkinson's drugs. These two substances have a very broad range of uses, but they rarely get highlighted. Clearly, they are not marketed well enough, PEA is not available in the US in high-quality formulations, and it is expensive. But citicoline is relatively cheap. (I use cognizin brand that seems to contain what it says.)
ConsumerLab.com
November 12, 2024We appreciate your feedback. We've added information about the use of citicoline and PEA for Parkinson's disease to the following sections of our article:
https://www.consumerlab.com/answers/supplements-for-parkinsons-disease/parkinsons-disease-supplements/#citicoline
https://www.consumerlab.com/answers/supplements-for-parkinsons-disease/parkinsons-disease-supplements/#pea
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Jeanne20921
October 21, 2024Then what can help Parkinson’s? There must be some helpful answers. I’ll read article also that was posted above about thiamine
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Chris20204
July 25, 2024What an I missing? DopaBoost has vitamin B6 in the form of P5P. Didn't this CL article just say taking B6 with L-dopa undermines both?
ConsumerLab.com
August 29, 2024Thank you for your question! To address this matter, we have updated our article with more details in the section provided below: https://www.consumerlab.com/answers/supplements-for-parkinsons-disease/parkinsons-disease-supplements/#dopaboost
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David15572
May 02, 2023I am surprised that Thiamine wasn't mentioned, there is a lot going on in that space right now. Daphne Bryan's book seems interesting, she is an old piano teacher who reversed her Parkinsons with B1. I found it on YouTube when I was researching my thiamine deficiency. Not sure what to make of it but thought you might want to add something about it. Dr. Costantini is at the heart of it, I think. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3762356/
ConsumerLab.com
January 02, 2024Although some preliminary research has suggested that high-dose injectable thiamin might improve certain movement and non-movement symptoms of Parkinson's disease, these studies did not include placebo groups, which are needed to prove a benefit. We are not aware of any studies evaluating thiamin supplementation for improving symptoms of Parkinson's disease.
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Parkinson's Patient
August 15, 2022This is not correct:
" However, vitamin B-6 can also reduce the effects of levodopa and should generally be avoided by people taking levodopa alone. Vitamin B-6 does not significantly affect carbidopa-levodopa (Sinemet)."
Background: Levodopa gets through the blood-brain barrier, whereas dopamine does not. The purpose of carbidopa is to prevent levodopa from being prematurely converted to dopamine before it crosses the blood brain barrier.
If vitamin B6 meets up with carbidopa in the GI tract they will form in insoluble complex, inactivating both. Yet B6 is an essential nutrient, especially Parkinson's patients because carbidopa depletes B6. The way around this problem is to allow an adequate time interval between ingestion of these 2 compounds - preferably 2 hours if possible.
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