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A toilet in an empty bathroom at night

Answer:

Needing to wake up more than once during the night to urinate, a condition known as nocturia, commonly occurs with age, affecting about 69% of men and 76% of women ages 40 and older (Weiss, Rev Urol 2012). Common causes of nocturia are urinary tract infections (UTIs), overactive bladder (OAB) and benign prostate hyperplasia (BPH), and there are many others. It’s important to talk to your doctor if you’re experiencing excessive nighttime urination to ensure that the correct cause of the condition is identified.

Depending on the cause of nocturia, evidence from small clinical trials suggest that certain supplements may be beneficial, while some others might not help.

Sign in as a member for details about the clinical evidence, dosage, and safety of supplements promoted for nighttime urination for men and women, including beta sitosterol, cranberry supplements, magnesium, pumpkin seed oil, saw palmetto, vitamin D and others.

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47 Comments

majid20151
July 21, 2024

Retraining my bladder has been very helpful for me. I try not to make frequent bathroom visits during the day. Many times, we go to bathroom for partially full bladder because of convenience.

RV
November 20, 2024

I'm a 75 y/o woman who used to wake up about every 2 hours during sleep to go to the bathroom. Instead using prescription meds which has severe side effects, I retrained my bladder by noting the times I go to the bathroom on my phone. I read that if one goes to the bathroom 8xs or more during a 24 hour period one has a problem. I also switched to Mirtazapine 3.75 for insomnia & 1mg of Melatonin. Now I go to the bathroom only 1x night, about 6-7xs during 24 hour pd., but I do wake up a few times but I return to sleep easily. So I figured out the frequent urination was due to anxiety underlying my insomnia. I also take Mat Pilates which works the pelvic floor, important for bladder control for both sexes!

Dewey20129
July 19, 2024

Varuna (Crateva nurvala) worked for me. I also started taking pumpkin seed oil. I'm down to once at night instead of four times a night.

ConsumerLab.com
July 23, 2024

Thank you for sharing your experience! As noted in our article, there is limited evidence that a product containing Crataeva nurvala can reduce nighttime urination in people with overactive bladder ( https://www.consumerlab.com/answers/supplements-for-nighttime-urination/nocturia/#urox), and a preliminary study suggests that pumpkin seed oil may improve urinary symptoms in men with BPH ( https://www.consumerlab.com/answers/supplements-for-nighttime-urination/nocturia/#pumpkin-seed).

LYNN20119
July 19, 2024

This study about Unox shows efficacy. < https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5793427/ > However, the possible effects of Crataeva lindera (horsetail) extract include increased urination and low potassium, and, with long-term use, vitamin B1 deficiency. How can we reconcile opposing effects? Low electrolyte levels can be expected with a diuretic like horsetail. That can lead to muscle cramps. I'm female, 76, and have both stress incontinence and get up at least 3 times a night to urinate, so I'm looking for solutions besides surgery.

ConsumerLab.com
July 23, 2024

Thank you for your comment! The study that we cite about Urox did not find Urox to be associated with any side effects, although the researchers did not appear to measure electrolyte levels.

Jo20115
July 19, 2024

I was getting up to urinate three times a night, and it was voluminous -- much more than I was urinating in the daytime. At the beginning of this article, sleep apnea was listed as a possible cause of nocturia. I was diagnosed with severe sleep apnea, and the very first night I used a CPAP I did not need to get up once. Since then, I've learned that nocturia can be a symptom of sleep apnea just as feeling sleepy in the daytime. The CPAP has helped me in numerous other ways (more energy, better decision making, enhanced cognition).

Harrison20103
July 19, 2024

Gemtesa (vibegron) 75 mgm daily extremely effective in urgency from bladder spasms and nocturia.

ConsumerLab.com
July 22, 2024

Be aware this is a prescription medication.

Lida19949
July 08, 2024

Is pumpkin seed oil as effective for women as it is for men in controlling nocturia?

ConsumerLab.com
October 30, 2024

Thank you for your inquiry. Unfortunately, there seems to be a lack of substantial evidence to address your question. The majority of studies assessing pumpkin seed oil for nocturia have been conducted solely with male participants. A study investigating pumpkin seed oil for overactive bladder did include both genders, but the significance of its findings is diminished by the absence of a control group. For more information on these studies, please refer to our Prostate Supplements Review: https://www.consumerlab.com/reviews/prostate-supplements-beta-sitosterol-phytosterols-saw-palmetto/sawpalmetto/#pumpkin-seed

Glenn17747
May 09, 2023

Woman here. Started taking glycine a few months ago to help with sleeping. I've limited myself to 1 gram for now. I have definitely noticed that my nighttime urination frequency is much less. I used to use the bathroom maybe 3x a night (I never counted this but that's my guess); I'm now using it about 1x a night. I feel less urgency to go when I've woken up between sleep cycles, so feel more comfortable falling back asleep even knowing/feeling that there's some urine in my bladder.

Casper
June 25, 2023

I'm finding the same results re glycine, 1 pill, 1 gm. It's only been 5 nights, but I'm going 5-6 hours before getting up to use the bathroom! I used to get up every 2-3 hours, which was 3-4 times a night to potty. So far on glycine, it's down to 1-2 times. Hope this lasts!

Claudia20184
July 23, 2024

Thank you for the post. I will try it.

Lorraine17745
May 08, 2023

I have been using NOW pumpkin seed oil, but a reviewer on Amazon complained about mold in the capsules (black spots). I started looking at the capsules I had and sure enough there was a blackish substance in it. Has Consumer Lab looked in to what is in the capsule that looks like mold? I have stopped taking them because they are not clear. I have no affiliation or interest in any particular brand of pumpkin see oil.

ConsumerLab.com
May 11, 2023

We have not tested the product that you mention but, as it is cold pressed from pumpkin seed, it could just be some material from the seed. On the NOW website page for this product they write: "Naturally occurring dark particulates may be visible in the pumpkin seed oil but do not affect the quality of the product.”

Cynthia18953
March 13, 2024

There was a reviewer on Amazon who commented on this brand and the complaints about it. He/she said that it's NOT A PROBLEM and is NOTHING TO WORRY ABOUT. NOW products are reported to be good by the users of them.

Nick17742
April 26, 2023

I have been taking 2000 mg of pumpkin seed oil for the past month or two. I have found that my urinary function has improved hugely and is not as good as it was 20 years ago. Sexual function has also improved dramatically.

ConsumerLab.com
April 30, 2023

Hi Nick, we've added information about pumpkin seed oil in the answer above. You can also find more information about the evidence for pumpkin seed oil, including dosage, in our Prostate Supplements Review https://www.consumerlab.com/reviews/prostate-supplements-beta-sitosterol-phytosterols-saw-palmetto/sawpalmetto/#pumpkin-seed.

daniel17743
September 24, 2023

how is it now? do you still take it regularly? which brand?

Jimmy17739
April 21, 2023

I suffered from nocturia for many years and tried every supplement that Consumer Labs mentioned. None of these really helped. Someone suggested that I might benefit from pumpkin seed oil. I tried the capsules and they did help somewhat, but I found out I was not at the therapeutic dosage. I starting taking a tablespoon of pumpkin seed oil at night before bed. Wow, what a difference. Take a brand of Styrian pumpkin seed oil.

ConsumerLab.com
April 28, 2023

Thanks for sharing your experience. We've added information to our article regarding the use of pumpkin seed oil for urinary symptoms of BPH ( https://www.consumerlab.com/answers/supplements-for-nighttime-urination/nocturia/#pumpkin-seed) and overactive bladder ( https://www.consumerlab.com/answers/supplements-for-nighttime-urination/nocturia/#pumpkin-seed-oab).

janice17737
April 17, 2023

what about cornsilk? it is reputed to help with nocturia, I found it helpful, as well as glycine, which is briefly mentioned above. also, a study does support glycine as a remedy. yarrow has been used for centuries, too,

ConsumerLab.com
April 21, 2023

We've added information about corn silk to the following section of our article: https://www.consumerlab.com/answers/supplements-for-nighttime-urination/nocturia/#corn-silk

Mark20171
July 23, 2024

I've been prescribed a drug, desmopressin which has been very effective in assuring I get a full night's sleep. It cause greater sweating, but other than that a regular, REM sleep is highly rewarding.

Lloyd17736
February 17, 2023

Im thinking about Axonic but i had rather use supplement to reduce frequent peeing day and night

StatinStories.com
October 10, 2022

Did anyone else start having nocturia problems after being put on a statin drug?

Maria17729
October 13, 2022

Yes! I had horrible nocturia, bladder and urethral pain and inflammation keeping me most of the night after starting statins. I started with atorvastatin 20mg, tried pravastatin 10mg but nothing changed until I went off statins and the problem stopped. I now take ezetimbe and 5mg rosuvastatin every other day and have no issues.

James17720
October 10, 2022

2 grams of pumpkin seed oil extract a day has helped me. 1st gel cap in the morning before eating and 2nd 1 gram gel cap with breakfast. I use the Now product.

Grant17716
October 08, 2022

I was having nocturia four times a night and started on Beta-Sitosterol and it did help ,maybe down to two times a night. I was taking Cranberry capsules three times a day but recently I switched to Cranberry softgels and it had immediate effect. Its been no times a night or just once after 7 hrs .
I take the CranRich Cranberry 500mg softgel and NOW 500mg Beta-Sitosterol softgel.

Arthur17718
November 25, 2022

Are you taking 1 each of the CranRich and NOW each day (or night)?

Roger17714
October 03, 2022

I take 60 mg of beta-sitosterol twice daily and usually get up once per night. Sometimes zero. Previously it was two to three.

Daniel17715
October 04, 2022

Which brand are you using?

Henry17712
October 02, 2022

I have significant BPH (75 cm postrate) and other symptoms but zero nocturia. For other things--like burning, hesitancy, slow riveretc.--I have found quercetin to be the only useful supplement. Point being, we each have to find what works for us personally, beyond what large studies show.

James17707
October 02, 2022

None of these so-called remedies and others have helped my nocturia.

Janet17711
October 07, 2022

My husband & I have discovered that taking 400 mg of ibuprofen at bedtime decreases our need to urinate during the night, and we keep much better!

ConsumerLab.com
October 09, 2022

Although there is some evidence that ibuprofen and other non-steroidal anti-inflammatory drugs (NSAIDs) may help to reduce nocturia (https://onlinelibrary.wiley.com/doi/10.1002/nau.23910; https://pubmed.ncbi.nlm.nih.gov/16455186/), the potential adverse effects of taking them regularly may outweight the benefit for many people.

Chris17709
April 25, 2023

I was taking ibuprofen multiple times a day and ended up getting stage 3 kidney disease, I stopped and my kidneys recovered after about 3 months. My doctor said not to take it again.

Claudia20185
July 23, 2024

I am told that is unhealthy to take on a regular basis.

Christine21766
January 28, 2025

Please be aware that Ibuprofen and other non-steroidal drugs slow down renal function. I would not recommend using these meds on a regular basis. I am a PA.

Betsy17702
September 30, 2022

It’s been a few years now so I don’t recall the dosage, but taking valerian root before bed greatly reduced the number of times I woke up to urinate. I used it for only a week or two before the problem disappeared entirely.

Martha17699
September 30, 2022

Frequent nighttime urination is also a symptom of sleep apnea. Now that I'm on CPAP therapy I no longer need to get up to the bathroom 5 times a night.

Paul17700
October 04, 2022

I've had the same experiences!

Lorraine17701
February 21, 2023

I also had the same experience, as well as using pumpkin seed oil.

Arnold17696
September 30, 2022

beta-sitosterol reduced my wake up time from 8 to 1 or even zero, but then it caused constipation. I was taking 375 mg/day and it took over a week to get results.

Arnold17698
September 30, 2022

I checked my records and found I had taken 375mg twice a day. At lunch and supper with meals.

ConsumerLab.com
September 30, 2022

As noted in the Concerns and Cautions section of our Prostate Supplements Review, constipation and other GI side effects have been reported in clinical research in a small percentage of men taking beta-sitosterol: https://www.consumerlab.com/reviews/prostate-supplements-beta-sitosterol-phytosterols-saw-palmetto/sawpalmetto/#cautions-betasitosterol

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