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Our Members Asked:
Are there supplements I should avoid when taking apixaban (Eliquis) or similar blood thinner drugs like Xarelto?
Answer:
Yes, several popular herbal supplements can impact the effectiveness of apixaban (Eliquis), rivaroxaban (Xarelto), betrixaban (Bevyxxa), and other anticoagulant drugs (blood-thinners) classified as direct factor Xa inhibitors.
These blood-thinners are broken down in the body by the liver enzyme CYP3A4. Supplements that activate this enzyme may reduce the amount of these medications in the body, while supplements inhibit this enzyme may lead to excessive blood levels of these medications.
Other supplements have their own blood-thinning or clot-promoting effects, which, correspondingly, may increase or reduce the effectiveness of these blood thinners.
Also, be aware that some supplements interact with the anticoagulant dabigatran (Pradaxa), a direct thrombin inhibitor.
Sign in as a member for details about which supplements can interfere with these anticoagulants and increase or decrease their effects. Also, find out which supplement that can interact with blood-thinners such as warfarin is unlikely to interact with apixaban (Eliquis) and other direct factor Xa inhibitors.
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17 Comments
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Trebor20406
August 17, 2024Does Consumer Lab have any specific reports of specific scientifically documented interactions between supplements and Eliquist (not another blood thinner)? My interest in this is based on the fact that I take Eliquis.
ConsumerLab.com
February 26, 2025For more information, please click on the links in our article above, which redirect you to our Reviews that contain more details, including whether an interaction has been reported in people taking Eliquis.
Reply to this post…
indeterminacy@msn.com
August 16, 2024which is the best silymarin
ConsumerLab.com
August 18, 2024Please see our Review of Milk Thistle Supplements (which contain silymarin) which includes our tests of products and our Top Picks https://www.consumerlab.com/reviews/milk-thistle-and-liver-supplements/milkthistle/#toppicks.
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Jocelyn20347
August 11, 2024what are the effects of vitamins - K2 and K1 and lettuce. on the body when taking eliquis
ConsumerLab.com
August 22, 2024We've added information about vitamin K and Eliquis to the following section of our article: https://www.consumerlab.com/answers/supplement-interactions-with-apixaban-eliquis/eliquis-supplement-interactions/#vitamink
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Frank11204
May 14, 2023Saw Palmetto and beta-sitosterol are sometimes described as having an interaction with blood thinners. Would either of them affect direct factor Xa inhibitors like Eliquis?
ConsumerLab.com
October 24, 2023Information about saw palmetto, beta-sitosterol and possible bleeding risk can be found in the Concerns & Cautions section of our Prostate Supplements Review: https://www.consumerlab.com/reviews/prostate-supplements-beta-sitosterol-phytosterols-saw-palmetto/sawpalmetto/#beta-sitosterol-bleeding
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Faye11200
May 13, 2023I take a lot of prescription drugs, one of which is Eliquis. Beginning to wonder if I
should chance taking ANY supplements. Seems like prescriptions and supplements are not made to "go together"!
gerry11201
December 23, 2023Much of it depends on how much of the supplements you're taking, as well as how many that are shown on the list.
Reply to this post…
Hampton11198
May 12, 2023This is VITAL INFORMATION (on supplement--blood thinner interactions) that I for one badly need, & have never been able to get in a systematic way anywhere else! Hampton P. Howell III, Ph.D.
ConsumerLab.com
May 14, 2023Thank you for your kind words, we're glad you've found this article to be helpful!
James18877
March 01, 2024I second Hampton's comment. Very valuable info.
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Michele11196
May 09, 2023does this include fresh garlic and fresh ginger or only suppliments
ConsumerLab.com
May 18, 2023Great question! Fresh garlic and fresh ginger have both been linked with blood thinning effects, as described in detail in our Reviews:
Garlic: https://www.consumerlab.com/reviews/garlic-supplements/garlic/#cautions
Ginger: https://www.consumerlab.com/reviews/ginger-supplement-review/ginger/#cautions
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Gloria11195
May 09, 2023Thank you! Thank you! This was most timely. I was just put on Eliquis and and only some of this information was on the pharmacy sheet!
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Mary Lou11185
November 13, 2020Thank you for the specific information.
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