Estrogen Creams for Wrinkles: Safety, Efficacy & Comparison of OTC vs. Rx

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Estrogen Cream for Wrinkles?

Written by Meredith Worthington, Ph.D. — Medically reviewed and edited by Tod Cooperman, M.D.

Updated October 02, 2024 ⓘ

Older woman applying estriol cream for wrinkles

Answer:

Menopause-related decline in estrogen levels has been linked with skin thinning, reduced elasticity, reduced skin healing, and accelerated skin aging (Kendall, Sci Rep 2022; Thornton, Dermatoendocrinol 2013). Consequently, there is interest in applying estrogen to the skin to delay these skin changes. Estriol, a weak estrogen hormone that is included in facial skin products such as Musely FaceRx The Aging Repair Cream, Alloy M4 Estriol Face Cream, and SMNutrition Estro-life Cream, has been investigated in several preliminary clinical studies for improving menopause-related skin changes.

Sign in as a member to learn if estriol creams appear to be helpful and safe for aging skin, and how "prescription" estriol and estradiol creams and gels (such as Estrace and Divigel) differ from OTC creams.

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