Estriol Cream for Wrinkles: Safety, Efficacy & Comparison of OTC vs. Rx

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Estriol Cream for Wrinkles

Written by Meredith Worthington, Ph.D. — Medically reviewed and edited by Tod Cooperman, M.D.

Updated September 30, 2024 ⓘ

Older woman applying estriol cream for wrinkles

Answer:

Menopause-related decline in estrogen levels has been linked with skin thinning, reduced elasticity, reduced skin healing, and accelerated skin aging (Kendall, Sci Rep 2022; Thornton, Dermatoendocrinol 2013). Consequently, there is interest in applying estrogen to the skin to delay these skin changes. Estriol, a weak estrogen hormone that is included in facial skin products such as Musely FaceRx The Aging Repair Cream, Alloy M4 Estriol Face Cream, and SMNutrition Estro-life Cream, has been investigated in several preliminary clinical studies for improving menopause-related skin changes.

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