Our Members Asked:
What is Pycnogenol, does it work, and is it the same as other pine bark extracts?

Answer:
Pycnogenol (Horphag Research), a branded extract from the bark of French maritime pine (Pinus pinaster, formerly Pinus maritima Poir.), is promoted for various uses due to its antioxidant and anti-inflammatory properties. Although clinical research has suggested that Pycnogenol may be beneficial for some of these conditions, many of the studies to date have been funded by the makers of Pycnogenol and some were small in size, which limits the impact of the results.
Other French maritime pine bark extracts, such as Flavangenol and Oligopin, have also been evaluated for certain conditions in clinical research, although these brands are much less studied that Pycnogenol. These products also differ slightly from Pycnogenol in how they are extracted: Pycnogenol is obtained by extracting with water and alcohol, while Flavangenol and Oligopin are obtained by extracting with only water (Marmol, Trends Food Sci Technol 2019; Segal, Toxicol Rep 2018), affecting the range of compounds in the extracts.
In addition to French maritime pine bark extract, some supplements contain bark extract from Pinus massoniana, a different pine species that is sometimes called Chinese red pine. This form of pine bark extract has been studied in only limited clinical research without apparent evidence of benefit.
Sign in as a member for details about clinical studies evaluating the effectiveness and safety of Pycnogenol and other pine bark extracts for conditions such as asthma, allergies, benign prostatic hypertrophy (BPH), blood clots during travel, chronic venous insufficient (CVI), arterial plaques and coronary artery calcifications, diabetic retinopathy, fibromyalgia, glaucoma, high blood pressure, knee osteoarthritis, Raynaud's phenomenon, sun protection, tinnitus, and varicose veins. Also, find out what to look for when selecting a pine bark extract supplement.
Note: Unfortunately, the current method of testing for compounds in Pycnogenol and other pine bark extracts can be easily fooled by the addition of peanut skin extract. Until a more reliable, validated method is developed, ConsumerLab.com is unable to test and review these products.
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Jane21993
February 18, 2025I usually get an idea to try a supplement, read Consumer Labs and then save my money.
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Dr Barbara20147
July 21, 2024Does anyone have experience with taking pycnogenol for glaucoma? If so, how much and what kind did you take, and what were the results?
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Jane18482
January 23, 2024I have heard that pine bark extract studies have shown an improvement in bone health. I have also read that people with auto immune issues should be cautious with it. Having osteoporosis and thyroid autoimmune disease, I am hesitant to try it. Are there any studies that focused on pine bark extract and autoimmune issues?
We are not aware of clinical studies showing that pine bark extract adversely affects thyroid function or symptoms of autoimmune disorders.
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Charlotte18468
January 19, 2024I've been taking pycnogenol since last spring (23) and it seems to stop my hot flashes very close to 100%. I recently missed a dose and had a few reduced flashes within hours.
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Stan3381
January 12, 2024Are there any studies related to pycnogenol or other supplements affecting the blood flow to the optic nerve & retina in some forms of glaucoma?
Great question! We've added information about Pycnogenol-containing supplements for people with glaucoma or elevated pressure within the eye to the following section of our article: https://www.consumerlab.com/answers/does-pycnogenol-work/pycnogenol/#pycnogenol-and-bilberry-glaucoma
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Virginia3380
January 12, 2024I read an article from a Swiss university about 10 years ago. It said Pycnogenol, Vitamin C, and Zinc taken together at the first signs of an URI would stop the progression of the URI. I have tried it, and to my surprise, it has worked for me most of the time. What do you know about that? Thanks.
We are aware of an older study that suggested Pycnogenol or a combination of Pycnogenol, zinc gluconate, and vitamin C might reduce symptoms and shorten the duration of the common cold (https://www.minervamedica.it/en/journals/Otorhinolaryngology/article.php?cod=R27Y2013N03A0151). Unfortunately, this study did not include a placebo group, which is needed to prove a benefit.
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Barbara3379
January 12, 2024We are a Costco customer. We've taken Trunature pycnogenol for many years. Why haven't you tested their brand? The main ingredient is procyanidins. Surely you've found it used widely.
As we explain in the following section of our article, the current method of testing for compounds in Pycnogenol and other pine bark extracts can be easily fooled by the addition of peanut skin extract. Until a more reliable, validated method is developed, ConsumerLab.com is unable to test and review these products: https://www.consumerlab.com/answers/does-pycnogenol-work/pycnogenol/#testing
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Mary3374
October 11, 2023I tried pycngenol a couple oof years ago & very prompt had an outbreak of herpes zoster, which sits dormant (ordinarily) in my system. I stopped taking the supplement & the herpes outbreak ended. Perhaps this was all coincidentally, but I'm hesitant to retry pycnogenol even thought I'd like to tackle some swelling in my feet & legs.
Thank you for sharing this, Mary. We aren't aware of any published reports of Pycnogenol triggering a shingles outbreak.
AnnAnn
January 12, 2024I have herpes which I successfully keep at bay with l-lysine. I have taken Pycnogenol for many years with no problem with herpes outbreak.
Michael3375
January 14, 2024Horse chestnut extract works well for my leg swelling - 20% aescin.
See our article about the safety and potential side effects and drug interactions with horse chestnut https://www.consumerlab.com/answers/can-horse-chestnut-cause-stomach-irritation/horse-chestnut-side-effects/.
J. Allison18465
January 19, 2024I have been taking 500mg Valacyclovir twice a day for many years to prevent breakouts of herpes Whitlow (herpes on one's hands). Last November, I had a small, yet very painful, breakout. It has lasted months. After reading Mary's comment about herpes shingles and Pycnogenol, I stopped taking it (Healthy Origins) and the breakout ceased. Hard to tell, of course, if there is cause/effect - maybe it had run it's course anyway. But I thought I should reflect my experience with you. And thank you, Mary.
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Gidget3368
February 12, 2023Regarding Raynauds: I have taken oil of evening primrose for many years. I had significant improvement in my fingers, toes, and legs (ability to stand still for more than a few minutes). 20 years ago I started taking this, on a recommendation from a hematologist/researcher.
Mimi
May 18, 2024This sounds wonderful. I have some issues with cold hands and feet from stress. How much evening primrose oil do you take?
Thank you so much for your information.
Maxine20399
August 16, 2024I have severe raynauds, I've been taking 300mg pine bark for years, it had no effect on my raynauds. Just sharing my experience. Maybe I'll try primrose
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Ed3350
February 10, 2023Is anyone aware of a Pycnogenol/Gotu Kola supplement other than Life Extension's Arterial Protect which is a buck a capsule? As for atherosclerosis, my calcium score doubled the year I was taking this. That is while eating super clean, exercising daily and having an LDL in the 60s.
Rob T
February 12, 2023I looked myself and decided that the LE combination was more convenient and less expensive than the alternative of DIY.
Valerie3362
February 13, 2023Sorry, are you saying that your CAC score dou led while you were taking the life extension version? Did you have your score tested before you started taking it and then again one year later?
L3356
December 11, 2023Swanson
Stuntman
January 12, 2024I buy the products separately. It's way cheaper.
sue3360
January 13, 2024It's my understanding that Arterial Protect helps stabilize/harden the soft plaque, which in turn increases your calcium score, just like a statin would. The soft plaque is more dangerous. I have no interest in Life Extension. I am not an expert.
raymond3351
January 14, 2024@Ed27…Statins are known to increase mineralization of arterial plaque, were you taking them?
Leslie3361
January 16, 2024I don;t know whether or not I have misunderstood the above, but I would have thought - and I am not fond of any kind of statin drug - that the intended purpose of them was to avoid arterial plaque..
Is there an article you may suggest on your claim.? Thank you..
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Julie3342
July 13, 2022Also, I should had to my previous post that while pycnogenol helped me with (less) menstrual blood loss and skin conditions, it didn't help at all with my tinnitus and fibromyalgia. (but that's my personal experience).
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Laura3327
November 23, 2019After suffering with Raynaud's phenomenon for many years, I decided to try Pycnogenol after reading the study you recently cited. It took a couple weeks, but I am cautiously optimistic. I am more comfortable being outdoors for long autumn walks and I am able to keep the thermostat a couple degrees cooler than before. My hands don't mottle. I'm just one person, but it's very exciting!
Kelly3332
March 08, 2022I know it has been a couple years now, do you think it helped? If so could you possibly provide the name of the Pycnogenol you used? Thank you!
Luanne3330
September 12, 2022I've used Swanson or Spring Valley Ginkgo Biloba 120 mg. 2×/day to stop my Raynaud's and nerve pain in my hands. Works great!!
I have no financial interest in either company. Ginkgo biloba works for Raynaud's and other nerve pain.
You can find more information about Gingko biloba and other supplements that may be helpful in our article about Raynaud's phenomenon https://www.consumerlab.com/answers/which-supplements-help-with-raynauds-phenomenon/supplements-for-raynauds/.
Michael3329
February 10, 2023RE: neuropathic pain (feet) - acetyl L carnitine 500mg, and alpha lipoic acid 600 mg; both taken every 12 hours - has a remarkable benefit - immediate (hours) relief, but the reduction in pain gradually improves over 3 weeks. I take lipoic acid immediately prior to eating, or with a lot of liquid on an empty stomach, to avoid heartburn/GERD. All brands work the same, as far as I can tell - I buy the ones on sale.
Hi Michael, you may be interested in our article about supplements and nerve pain https://www.consumerlab.com/reviews/acetyl-l-carnitine-supplements-review/acetyl-l-carnitine/#whatitdoes. Also see our Reviews of Acetyl-L-Carnitine Supplements https://www.consumerlab.com/reviews/acetyl-l-carnitine-supplements-review/acetyl-l-carnitine/#whatitdoes and Alpla Lipoic Acid Supplements https://www.consumerlab.com/reviews/alpha-lipoic-acid-supplements/alphalipoic/.
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Karl3326
October 28, 2019A Blaylock Wellness Report once mentioned that Pycnogenol was used by marathon runners to prevent Charlie horses. As a runner, I have used Pycnogenol effectively to treat Charlie horses until I found grape seed extract had the same active ingredient at a lower cost.
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Marla3322
October 27, 2019I have a high platelet count, but won’t take baby aspirin since it caused a gastrointestinal bleed. Would Pycnogenol be a good alternative?
Hi Marla - There does not seem to be enough evidence to rely on Pycnogenol for your condition. You should discuss alternatives with your health care provider.
Bonnie
March 26, 2022My husband's platelet count improved considerably when he started getting at least a cup of berries every day.
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CHRISTOPHER3318
June 11, 2019CONSUMER LAB: Can you please further explain the last entry of your commentary: "....people taking blood-thinning drugs such as aspirin, Plavix ect...." How does Pycnogenol affect Plavix or anti-platelet drugs and/or even Brillenta?
Thank you,
Chris
Hi Chris - As discussed in our full answer above, due to an effect on platelets, Pycnogenol may potentially increase the risk of bleeding and should be used with caution with blood-thinning medications.
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Henry3317
May 19, 2019Having tried French Pine Bark Extract without any noticeable effect my research has led me here. I think I may benefit from Flavangenol but I can only find beauty products using this extract. How can I purchase the orally administered Flavangenol cited in the research papers that I have read.
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George M3314
March 16, 2019Is Pycnogenol equivalent to Pine Bark Extract? Are the alleged benefits limited to the French maritime source? I have seen PBE supplements that are much much cheaper, but sourced from Chinese Red Pine, or other locations.
Hi George - Pycnogenol is a standardized, branded form of pine bark extract. As noted in the answer above, most of the available research has used this brand; if you want to try another brand, it would be best to try one that it is standardized to a similar percentage of proanthocyanidins as Pycnogenol.
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JARKKO3309
September 26, 2018I hope ConsumerLab will test Oligopin(R) products. Pycnogenol(R) products I can already trust as Pycnogenol has been used in numerous clinical studies, but Oligopin is much cheaper than Pycnogenol. Oligopin and Pycnogenol are both made in France and from same plant, but by different French companies.
Oligopin has been also clinically studied, but much less than Pycnogenol.
Hi Jarkko - Thank you for your suggestion. Although we would like to test these products (and have wanted to for several years), there are no specific assays or reference materials for oligomeric proanthocyanidin compounds in these products, preventing us from reviewing them. This is the same problem we face with grape seed extract ( https://www.consumerlab.com/answers/what-are-the-benefits-of-grape-seed-extract/grape-seed-extract/ and cranberry ( https://www.consumerlab.com/answers/can-cranberry-help-with-utis/cranberry-urinary-infection/.
Bemular
November 28, 2018You say that you can trust Pycogenol(R) products; however, is there any guarantee that the various brands all contain exactly what is labelled on the bottle (re. dosage and absence of contaminants)? It seems to me that without ConsumerLab conducting independent and objective tests, the best we can do is go with a reputable brand and hope for the best.
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Paula3298
July 20, 2015Does it matter if it's taken with or without food?
Hi Paula - In most studies Pycnogenol was taken with a meal, but it's not clear if this was to improve absorption or to minimize the chance of gastrointestinal upset.
Monika3301
November 19, 2015I am taking 20mg of xeralto once a day, could I benefit from pine bark
Hi Monika - We are not aware of studies comparing Pycnogenol to Xeralto (a prescription anti-coagulant to prevent deep vein thrombosis) or assessing their combined use. We suggest you consult your physician about this -- and be aware that pine bark extract (Pycnogenol) may increase the risk of bleeding in people taking certain blood-thinning medications.
deborah3299
March 24, 2023I have taken citrus bioflavinoids for years for tinnitus. It really seems to work! I get innitus rarely, only in the evenings, and for a short time. I am not interested in discontinuing it to see if the tinnitus comes back! But I do strongly suggest it.
EL Chen
August 13, 2023Thank you Debora! - I took citrus bioflavinoids (La Femme Vein Support) a while back, and alleviated my symptoms significantly. But I can no longer find those anymore. Other brands didn't help. Which brand are you taking, and where did you purchase it from? Thank you for your help!
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Al3295
July 08, 2015I can submit first-hand anecdotal evidence on the use of Pycnogenol for tinnitus. I've had that condition for at least 15 years. Reading about a study whereby taking 150 mg of Pycnogenol daily for at least 4-6 months reduced symptoms in about 85% of sufferers, I gave it a try. I used Swanson brand briefly for about two weeks than used Healthy Origins brand for the rest of the time. I took 150 mg daily, faithfully from last October 2 until well into May this year. Results: zero, zip, none. No improvement whatsoever. Guess I'm a 15%-er.
I should state the obvious: your mileage may vary. I don't have Meniere's. I do have episodic BPPV. The tinnitus comes and goes from day to day, hour to hour. I've found the best treatment is to just ignore it. I have some hearing loss and that is harder to ignore, but I don't let it control my life. It's amazing what you can do with your mind if you decide to control it rather than letting it control you. If I had applied that Rx back in October, I could have save a bucket full of money because Pycnogenol isn't cheap. Live and learn.
Angela3297
April 22, 2017It's amazing what you can do with your mind if you decide to control it rather than letting it control you.
Thank you for sharing!
David3296
October 25, 2022Tinnitus can be caused by B12 deficiency, mine comes and goes commensurate with my sublingual usage
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wayne3288
June 05, 2015I have heard that Pycnogenol should not used if one has an enlarged prostate is there any recent info regarding this
Hi Wayne - There do not appear to be any studies regarding Pycnogenol use and prostate enlargement. Can you let us know where you read or saw this information?
Ronald3291
July 08, 2015Hi,
I do not know whether I have reduced the size of my enlarged prostate but within only a couple of weeks of taking stabilised electrolytes of oxygen I now have normal and pain free urination. It also quickly eliminated a persistant and inflamed sore on my leg by applying it externally.
Hi Ron - We have answered a question about a product, CELLFOOD, which includes dissolved oxygen among its ingredients. You can read more about that here: https://www.consumerlab.com/answers/does-cellfood-really-work/cellfood/
Michael3293
January 14, 2024Oxygen is very poorly soluble in water. The amount of O2 in water as a supplement, is too small to be of any benefit (or harm) - unless you're in a hyperbaric chamber. That's why hemoglobin exists to transport oxygen.
Thanks for your comment. As we note in our article about CELLFOOD, "...the most effective method to get oxygen to our tissues and muscles is breathing. Ingesting oxygen will not enhance this process." ( https://www.consumerlab.com/answers/does-cellfood-really-work/cellfood/)
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Elizabeth3283
February 18, 2015There is some information on the web that it should not be taken for longer than 6 months. I would like to know why but your explanation did not address this.
Hi Elizabeth - This recommendation may have been based on clinical studies using Pycnogenol which lasted for 6 months, although it has been used in clinical studies for up to one year and been well-tolerated. Please see the information we have added about this in the "Safety" section of the Answer.
Peg3286
November 24, 2023I came accross Pycnegol around 1994-5. It was sold by a MLM company and came in the form of tablets. I starated taking this daily and after about 2- 3 weeks, noticed an improvement in my eyesight. 2 or 3 others who also started with this product noticed the same thing. I was aged 60 at the time and just beginning to buy about 1.25 reading glasses. With pycnogenol, I never had to buy reader assisting glasses until I was around 80 and never more than 1.50 magnafication. About a year or two ago, my opthamologist asked me what I was taking, I only saw him about every 3-5 years, and I told him about the product. I was careful to use only a product stamped with guarantee about the French Maritime Pinebark and strength. Never took more than 100mg per day and I still use no more than 1.75 maginification. I was not the only to find eyesight improvement. I'm 88 now.
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Glen3278
February 18, 2015Horphag would have you believe all the health benefits from OPC are exclusive to pine bark extract (pycnogenol), however the bulk of research originating out of France from roughly 1950 to 1980 was done with grape seed extract. Cyvex Technologies in Irvine has an excellent source of OPC they label as "BioVin". Horphag is aggressively sponsoring studies to position pycnogenol as superior to GSE but that is simply not the case and GSE is a lot cheaper.
Bev L
December 05, 2023I have taken pine bark pycnogenol for 30+ years to help with symptoms of fibromyalgia, interstitial cystitis and migraines. I did a blinded study on myself (with my husband's help) many years ago: I compared the effect of grape seed extract with the pine bark version. Took each for two weeks. Turned out, at the end of a month, the pine bark extract worked well for my symptoms, and grapeseed did not. I have no connection to any seller or manufacturer of the product.
JARKKO3282
January 09, 2024Which brands, products and dose in mg did you try?
Barbara20758
October 01, 2024Hi Bev,
What brand and strength have you been taking for 30 years? I’d love to try it.
Barbara20759
October 01, 2024Did you take Pine Bark pycnogenol with any other supplement such as Bilberry or was it a stand alone supplement?
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