Conolidine: Evidence for Pain Relief, Safety, and CONOCB2™ Products Explained

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Conolidine for Pain

Written by Meredith Worthington, Ph.D. — Medically reviewed and edited by Tod Cooperman, M.D.

Updated August 26, 2024 ⓘ

Three commercial products that contain conolidine

Answer:

Conolidine — the main ingredient in CONOCB2™ Blend, a proprietary ingredient found in products such as Conolidine Liquid, Conolidine Topical, and Conolidine FROST, all by Gameday Ready Labs — is an indole alkaloid compound naturally found in very small amounts in the stem bark of crepe jasmine (Tabernaemontana divaricate). The stem bark of crepe jasmine has been used for centuries in traditional Chinese, Thai, and Ayurveda medicine to treat fever and pain. There is interest in using conolidine as a pain-reliever based on evidence from animal research suggesting that it may reduce pain without the side effects of opioids (Flight, Nat Rev Drug Discov 2011).

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Also see these articles about supplements for pain: "Do any supplements, like Nervive, help with nerve pain, like sciatica or diabetic neuropathy?" and "Is topical menthol, such as Biofreeze, safe and effective for pain relief?"

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