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Our Members Asked:
Are there supplements, foods, or beverages that I should avoid when taking clopidogrel (Plavix)?
Answer:
Yes, certain supplements may increase or decrease the effectiveness of clopidogrel (Plavix). This can increase the risk of bleeding or, conversely, increase the risk of blood clots. Clopidogrel is a "prodrug," meaning it must be broken down by the body to become active. Two liver enzymes, CYP3A4 and CYP2C19, are responsible for this. Consequently, supplements that inhibit these enzymes may reduce the effectiveness of clopidogrel, while supplements that that induce these enzymes may increase the activity of clopidogrel. Certain beverages and foods may also affect this drug.
Sign in as a member for details, including information on the effects of ashwagandha, cannabidiol (CBD), cocoa and dark chocolate, curcumin and turmeric, fish oil, garlic, ginkgo, grapefruit juice, melatonin, and other supplements, on the antiplatelet activity of clopidogrel.
In addition the results of its expert testing, ConsumerLab uses only high-quality, evidence based, information sources. These sources include peer-reviewed studies and information from agencies such as the FDA and USDA, and the National Academy of Medicine. On evolving topics, studies from pre-print journals may be sourced. All of our content is reviewed by medical doctors and doctoral-level experts in pharmacology, toxicology, and chemistry. We continually update and medically review our information to keep our content trustworthy, accurate, and reliable. The following sources are referenced in this article:
- Gao, Fitoterapia 2014
- Holmberg, Clin Pharmacol Ther 2014
- Iffland, Cannabis Cannabinoid Res 2017
- Kim, Die Pharmazie 2012
- Kim, Life Sci 2004
- Klotz, Epilepsia 2019
- Mathews, Drug Metab Dispos 2005
- U.S Department of Health
- Wang, Clin Pharmacol Ther 2004
- Wang, Clin Pharmacol Ther 2004
- Yin, Pharmacogenetics 2004
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