Can any supplements reverse gray hair?

Latest Update

Spermidine for Gray Hair?

Medically reviewed and edited by Tod Cooperman, M.D.

Written by Meredith A. Worthington, Ph.D.

Updated July 24, 2025 ⓘ

A young woman shows gray hair on her head on a white background

Answer:

Gray hair is a common condition that affects nearly 75% of adults between the ages of 45 and 65 (Panhard, Br J Dermatol 2012). While gray hair can be colored with hair dyes, many people are interested in reversing or delaying the progression of gray hair with supplements. But does any supplement really help?

Sign in as a member to learn what may help and what doesn't. We discuss the evidence for catalase enzymes, glutathione, iron, para-aminobenzoic acid (PABA), Polygonum multiflorum (He Shou Wu or fo-ti), spermidine, ubiquinone, and vitamins B-5, B-12, and C, as well as the hair products Mayraki and GR-7, used by "Don't Die" campaigner, Bryan Johnson.

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In addition the results of its expert testing, ConsumerLab uses only high-quality, evidence based, information sources. These sources include peer-reviewed studies and information from agencies such as the FDA and USDA, and the National Academy of Medicine. On evolving topics, studies from pre-print journals may be sourced. All of our content is reviewed by medical doctors and doctoral-level experts in pharmacology, toxicology, and chemistry. We continually update and medically review our information to keep our content trustworthy, accurate, and reliable. The following sources are referenced in this article: